Results 31 to 40 of about 1,353,697 (268)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Short term effects of irradiance on the growth of Pterocladiella capillacea (Gelidiales, Rhodophyta) [PDF]

, 2019
Pterocladiella capillacea has been economically exploited for agar extraction in the Azores for many years. Harvesting dropped to a full stop in the early 1990s due to a population collapse, but restarted in 2013.
Abreu, Maria H., Buschmann, Alejandro H., Carreiro, Ana S., Lloveras, Anna A., Neto, Ana I., Patarra, Rita F.   +5 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Liofilização: ciência ou arte? [PDF]

, 2014
The freeze-drying (lyophilization) process is defined as a stabilizing process in which a substance is first frozen and then the quantity of the solvent (generally water) is reduced, first by sublimation and then desorption to values that will no longer ...
I. Bartolomeu, Ana M.
core   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Português, língua de ciência? [PDF]

, 2016
Não é possível ignorar que para ter peso no panorama científico global, em muitas áreas, a divulgação tem de fazer do inglês o veículo fundamental. Esta imposição do inglês como única língua de ciência pode contribuir para uma menorização das outras ...
Teixeira, José
core  

Contributo dos blogues de ciência para a construção da literacia científica cívica no século XXI [PDF]

, 2013
Numa sociedade marcada pela superabundância de informação que exige, cada vez mais, o posicionamento crítico dos cidadãos, os blogues de ciência constituem um dos modos de interação possível para o debate de tópicos com relevância para um exercício de ...
Malho, Arminda, Melão, Dulce, Pereira, Isabel   +2 more
core   +2 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Acerca de los "hábitos artificiales" en la antropología luliana y el ascenso espiritual del hombre [PDF]

, 2005
The concept of "habitus artificialis" in lullian anthropology involves the knowledge of the divines virtues -the nature's secrets-, and it represents the spiritual way of human being. Similarly, some documents of medieval universities contain the natural
Higuera Rubio, José, Instituto Brasileiro de Filosofia e Ciência Raimundo Lúlio   +1 more
core   +1 more source