Results 181 to 190 of about 1,882,868 (239)

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Ciencia y Poder Aéreo, 2006
Ciencia & Poder Aéreo
doaj   +1 more source

Methane Catalytic Amidation via a Plausible Copper-Nitrene Intermediate. [PDF]

J Am Chem Soc
Martínez-Laguna J, Cholewinska A, Borrego E, Besora M, Álvarez M, Caballero A, Pérez PJ.   +6 more
europepmc   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Distinctive Behavior and Selective Modulation of PPARγ by Pentacyclic Triterpenoid Pomolic Acid and Hederagenin from <i>Rosa canina</i>. [PDF]

J Agric Food Chem
Nicola-Llorente M, Hermoso-Pinilla FJ, Torres-Oteros D, Luque FJ, Canudas S, Marrero PF, Haro D, Relat J.   +7 more
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Urbanization Shapes Dietary Composition and Snout Morphology of Salamanders. [PDF]

Mol Ecol
Marques AJD, Alarcón-Ríos L, Mata VA, Velo-Antón G.   +3 more
europepmc   +1 more source

Ciencia y ciencia ficción [PDF]

, 2003
Barceló, Miquel
core  

Prior Expectations Bias Confidence Judgments Through Parietal Alpha‐Band Modulation

Advanced Science, EarlyView.
ABSTRACT Humans possess the metacognitive ability to estimate the likely accuracy of their own decisions through confidence judgments. Yet, whether prior information shapes confidence and the neural mechanisms mediating such influence, remain to be determined.
Luca Tarasi, Anna Pasini, Domenico Romanazzi, Margherita Covelli, Vincenzo Romei   +4 more
wiley   +1 more source

Structural Mechanism of an Efficacy Photoswitch Targeting the β₂-adrenergic Receptor. [PDF]

Angew Chem Int Ed Engl
Stipp R, Bertrand Q, Trabuco M, Duran-Corbera A, Ignazzitto MT, Glover H, Stierli F, Catena J, Carrillo M, Hartmann S, Seidel HP, Mulder M, Mason T, Kondo Y, Wranik M, Appleby M, Sager C, Sierra R, Gate G, Schleissner P, Cheng X, Weinert T, Cheng R, Mous S, Beale JH, Kepa M, Llebaria A, Hennig M, Rovira X, Standfuss J.   +29 more
europepmc   +1 more source