Results 201 to 210 of about 1,862,700 (239)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Metabolic profile and skeletal muscle as predictors of survival in testicular germ cell tumors. [PDF]

Oncologist
Barrón-Hernández A, Ríos-Rodríguez JA, García-Pacheco JA, Cuevas-Estrada B, De-la-Rosa S, Castro-Hernández C, Jiménez-Ríos MA, Sobrevilla-Moreno N, Santibáñez-Andrade M, González-Barrios R.   +9 more
europepmc   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Fabrication of Stochastic Ni@PVP Nanowire Networks for Memristive Platforms. [PDF]

Polymers (Basel)
Lemos C, Dias C, Costa RS, Ventura J.
europepmc   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Ciencia y pasión y ciencia [PDF]

, 2006
Lalueza Fox, Carles
core   +2 more sources

Experimental Assessment of the Effect of Temperature in the Range of 20-80 °C on Structural Behaviour of NSM CFRP Reinforced Concrete Slabs. [PDF]

Materials (Basel)
Silva P, Abdulrahman HH, Escusa G, Correia L, Azenha M, Sena-Cruz J.   +5 more
europepmc   +1 more source

Selective CO₂ Electroreduction to CO by an Organometallic Nickel Catalyst Featuring a C₃-Symmetric Tris(Phosphino)Alkyl Ligand. [PDF]

ACS Catal
Fernández S, Michaliszyn K, Smirnova ES, Robert M, Luis JM, Lloret-Fillol J.   +5 more
europepmc   +1 more source

Correction: Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy.

Analyst
González-Vegas R, Seksek O, Bertho A, Bergs J, Hirayama R, Inaniwa T, Matsufuji N, Shimokawa T, Prezado Y, Yousef I, Martínez-Rovira I.   +10 more
europepmc   +1 more source

Optimisation of Alginate Extraction and Characterisation of Polysaccharides from Brown Seaweed from the Portuguese Coast. [PDF]

Mar Drugs
Mendes JC, Valente JFA, Sousa F, Bernardino R, Bernardino S, Afonso C, Chagas B.   +6 more
europepmc   +1 more source