Results 191 to 200 of about 1,862,700 (239)

ChloroScan: Recovering Plastid Genome Bins From Metagenomic Data. [PDF]

Mol Ecol Resour
Tong Y, Marcelino VR, Turnbull R, Verbruggen H.   +3 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Origin of eukaryotic plasmalogen biosynthesis by horizontal gene transfer from myxobacteria. [PDF]

Proc Natl Acad Sci U S A
Trinidad-Barnech JM, Rey Navalón ID, Mitsi K, Monera-Girona AJ, Najle SR, Padmanabhan S, Ruiz-Trillo I, Elías-Arnanz M.   +7 more
europepmc   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

<i>Enterococcus thailandicus</i>: Genomic evidence of a potential new player in enterococcal virulence and antimicrobial resistance. [PDF]

New Microbes New Infect
Vázquez-Ucha JC, Almeida-Santos AC, Velasco D, Rodríguez-Pallares S, Outeda-García M, Rodríguez-Coello A, Fernández A, Aja-Macaya P, Novais C, Beceiro A, Peixe L, Freitas AR, Bou G.   +12 more
europepmc   +1 more source

Coupled Above‐ and Belowground Ecosystem Stability Worldwide

Advanced Science, EarlyView.
Are the worlds above and below our feet in sync? This global exploration reveals an entangled fate between above‐ and belowground ecosystem stability. It identifies arid regions as hotspots for this coupling and highlights temperature stability as a vital safeguard for maintaining ecosystem balance across our warming planet.
Zexin Meng, Huiwen Li, Yiping Wu, Peter B. Reich, Nico Eisenhauer, Diego Abalos, Daniel Revillini, Shuguang Liu, Wende Yan, Ji Chen, Alexey Voinov, Zhifeng Yang, Ying‐Ping Wang, Fubo Zhao, Linjing Qiu, Jingfeng Xiao, Shantao An, Guopeng Liang, Manuel Delgado‐Baquerizo   +18 more
wiley   +1 more source

Ribcage Morphology in Native South American Populations From Different Altitudes: Insights From a Global Comparative Framework. [PDF]

Am J Hum Biol
López-Rey JM, D'Angelo Del Campo MD, Bettera Marcat G, Arrieta M, Fabra M, Salega S, Mercolli P, Seldes V, García-Martínez D, Bastir M.   +9 more
europepmc   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Correction to "AI-Driven <i>De Novo</i> Design and Development of Nontoxic DYRK1A Inhibitors". [PDF]

J Med Chem
García EG, Varas Pardo P, González-Naranjo P, Ulzurrun E, Marcos-Ayuso G, Pérez C, Páez JA, Insua DR, Santana SR, Campillo NE.   +9 more
europepmc   +1 more source