Results 261 to 270 of about 3,488,373 (301)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Screening of Mercury Bioaccumulation in Birds (Passeriformes) from a Major Wetland of the Brazilian Cerrado. [PDF]

Bull Environ Contam Toxicol
Monteiro LC, Caparroz R, Junqueira ML, Vogeley PH, Vieira LCG, Bernardi JVE.   +5 more
europepmc   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Synthesis of Tronocarpine Framework via a Michael/Lactamization/Michael Cascade Process: Synthesis of Dihydrotronocarpine. [PDF]

J Org Chem
Castañón-Garcíaa M, Escalantea CH, Mirandaa LD.   +2 more
europepmc   +1 more source

Coupled Above‐ and Belowground Ecosystem Stability Worldwide

Advanced Science, EarlyView.
Are the worlds above and below our feet in sync? This global exploration reveals an entangled fate between above‐ and belowground ecosystem stability. It identifies arid regions as hotspots for this coupling and highlights temperature stability as a vital safeguard for maintaining ecosystem balance across our warming planet.
Zexin Meng, Huiwen Li, Yiping Wu, Peter B. Reich, Nico Eisenhauer, Diego Abalos, Daniel Revillini, Shuguang Liu, Wende Yan, Ji Chen, Alexey Voinov, Zhifeng Yang, Ying‐Ping Wang, Fubo Zhao, Linjing Qiu, Jingfeng Xiao, Shantao An, Guopeng Liang, Manuel Delgado‐Baquerizo   +18 more
wiley   +1 more source

Effects of COVID-19 on Corneal Transplants Across the Five Regions of Brazil and Trends in Post-Pandemic Recovery-A Cross-Sectional Study. [PDF]

Health Sci Rep
Lessa JG, de Melo AS, Baldon LV, Carvalho BGL, Guimaraes NS, Soares AN, Trindade BLC, Ludolf F.   +7 more
europepmc   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Association Between Biochemical, Inflammatory, Oxidative Stress and DNA Methylation Biomarkers with Perceived Stress in Mexican Individuals. [PDF]

Biomolecules
Jacobo-Cuevas H, González-López L, Ramírez-de-Los-Santos S, Saldaña-Cruz AM, Ponce-Guarneros JM, Rodríguez-Jimenez NA, Brambila-Tapia AJL.   +6 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Characterization of a novel panel of polymorphic microsatellite loci and the mitogenome for the Neotropical marsupial Gracilinanus agilis (Didelphimorphia: Didelphidae). [PDF]

Mol Biol Rep
da Silva MRD, Lima-Rezende CA, Zangrandi PL, Mendonça AF, Caparroz R, Vieira EM, Rodrigues FP.   +6 more
europepmc   +1 more source