Results 81 to 90 of about 380,265 (254)

Accelerated Epigenetic Aging in Frontotemporal Dementia Highlights Smoking, Inflammation, and Metabolic Signals

Annals of Neurology, EarlyView.
Objective Epigenetic clocks are biomarkers of biological aging influenced by lifestyle and systemic factors. Accelerated epigenetic aging has been associated with neurodegeneration, but its relevance in frontotemporal dementia is unclear. We investigated biological aging in frontotemporal dementia using the GrimAge2 epigenetic clock, a DNA methylation ...
Daphne Nijland, Sven J. van der Lee, Eska Marye de Haan, Naren Ramesh, Sterre C.M. de Boer, Everard G.B. Vijverberg, Henne Holstege, Yolande A.L. Pijnenburg, Roel A. Ophoff, Lianne M. Reus   +9 more
wiley   +1 more source

Synthesis of Vegetable-Based Activated Carbons with Mixed Micro- and Mesoporosity for Use in Cigarette Filters [PDF]

, 2012
Activated carbons with micropores for adsorption and filtration of the volatile constituents of mainstream cigarette smoke, together with mesopores for enhanced mass transport were prepared by a novel route.
Parkes, Gareth M B, Dawson, Elizabeth A., Parkes, Gareth M.B, Peter Branton, Elizabeth A. Dawson, Branton, Peter, Gareth M.B. Parkes   +6 more
core   +2 more sources

Secondhand smoke (SHS) exposure is associated with circulating markers of inflammation and endothelial function in adult men and women [PDF]

, 2009
AIMS: Secondhand smoke (SHS) exposure is associated with elevated CHD risks. Yet the pathways through which this may operate have not been investigated in epidemiologic studies with objective SHS exposure measures and a wide range of CHD risk factors ...
Lowe, G.D.O., Welsh, P, Lowe, GDO, Jefferis, B. J., Whincup, PH, Ebrahim, S, Wannamethee, S.G., Jefferis, B.J., Lawlor, D. A., Rumley, A., McMeekin, L., Ebrahim, S., Whincup, P. H., Cook, D. G., Wannamethee, SG, Jefferis, BJ, Welsh, P., Lowe, GD, Feyerabend, C, Wannamethee, S. G., Lowe, G. D. O., Whincup, P., Feyerabend, C., Doig, M., Lawlor, DA, Cook, D.G., Carson, C., Doig, M, Rumley, A, Cook, DG, Carson, C, McMeekin, L, Lawlor, D.A.   +32 more
core   +1 more source

The Association Between Systemic Inflammation as Measured by Calprotectin and Autoantibody Load in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Plasma calprotectin is a marker of neutrophil activity. Its relation to the clinical phenotype and autoantibodies in rheumatoid arthritis (RA) is only partly understood. We therefore aimed to investigate the association between calprotectin and the clinical parameters C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti–cyclic
Caroline Grönwall, Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Nasim Ghasemzadeh, Niels Steen Krogh, Siri Lillegraven, Espen Haavardsholm, Martina Johannesson, Tore K. Kvien, Johan Rönnelid, Tue Wenzel Kragstrup, Bente Glintborg, Merete Lund Hetland, Hilde Berner Hammer, Danish Rheumatologic Biobank Study Group, Swedish Rheumatology Quality Register Biobank Study Group, Oliver Hendricks, Estrid Høgdall, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Carl Turesson, Solbritt Rantapää Dahlqvist, Lena Björkman, Alf Kastbom, Eva Baecklund, Johan Askling   +34 more
wiley   +1 more source

One Last Puff?: Public Smoking Bans and Smoking Behavior [PDF]

This paper investigates the short-term effects of public smoking bans on individual smoking behavior. In 2007 and 2008, state-level smoking bans were gradually introduced in all of Germany's sixteen federal states. We exploit this variation in the timing
Thomas Siedler, Michael Kvasnicka, Silke Anger   +2 more
core   +4 more sources

In vivo cigarette smoke exposure decreases CCL20, SLPI, and BD-1 secretion by human primary nasal epithelial cells.

Frontiers in Psychiatry, 2016
Smokers and individuals exposed to second hand cigarette smoke (SHCS) have a higher risk of developing chronic sinus and bronchial infections. This suggests that cigarette smoke (CS) has adverse effects on immune defenses against pathogens.
James eJukosky, James eJukosky, Benoit J. Gosselin, Leah eFoley, Tenzin eDechen, Steven N. Fiering, Mardi A. Crane-Godreau   +6 more
doaj   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Why Do Europeans Smoke More than Americans? [PDF]

While Americans are less healthy than Europeans along some dimensions (like obesity), Americans are significantly less likely to smoke than their European counterparts. This difference emerged in the 1970s and it is biggest among the most educated.
Edward L. Glaeser, David M. Cutler
core  

The impact of pharmacogenetic‐informed care on medication adherence and psychological factors associated with adherence: A narrative review

British Journal of Clinical Pharmacology, EarlyView.
Improvement in medication adherence is often proposed as a potential advantage of pharmacogenetic‐guided prescribing over a traditional one‐size‐fits‐all approach. This paper provides a review of the published literature and presents the findings of studies that measure adherence to medication as an outcome of pharmacogenetic‐informed care, or that ...
Lucy Galloway, Alison Wright, John Weinman   +2 more
wiley   +1 more source

Evaluation of antioxidant effect of resveratrol on testicular tissue in rats that were exposed to cigarette smoke

Urology Research and Practice, 2019
Objective: The aim of this study was to investigate the negative effects of cigarette on testicular biochemistry and histology of rats and to evaluate if resveratrol could alter these effects. Materials and methods: Thirty-two male Wistar Albino rats
Haluk Söylemez, Yahya Murat Uğraş, Ali Beytur, Fatih Oğuz, Meltem Kuruş, Aysun Bay Karabulut   +5 more
doaj   +2 more sources