Synergistic Anti-Inflammatory Activity of Apolipoprotein A-I and CIGB-258 in Reconstituted High-Density Lipoproteins (rHDL) against Acute Toxicity of Carboxymethyllysine in Zebrafish and Its Embryo [PDF]
PharmaceuticalsCIGB-258 is a 3 kDa altered peptide ligand from heat shock protein (HSP) 60 that exhibits anti-inflammatory activity against the acute toxicity of carboxymethyllysine (CML) with antioxidant and anti-glycation activities via protection of high-density ...
Kyung-Hyun Cho +4 more
doaj +5 more sources
CIGB-258 Exerts Potent Anti-Inflammatory Activity against Carboxymethyllysine-Induced Acute Inflammation in Hyperlipidemic Zebrafish via the Protection of Apolipoprotein A-I. [PDF]
Int J Mol Sci, 2023 Inflammation and atherosclerosis are intimately associated via the production of dysfunctional high-density lipoproteins (HDL) and modification of apolipoprotein (apo) A-I.
Cho KH +5 more
europepmc +4 more sources
CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients. [PDF]
Cell Stress Chaperones, 2021 Hyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand (APL) derived from the cellular stress protein 60 (HSP60).
Hernandez-Cedeño M +8 more
europepmc +5 more sources
Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and Functionality. [PDF]
Int J Mol Sci, 2022 Background: Hyperinflammation is frequently associated with the chronic pain of autoimmune disease and the acute death of coronavirus disease (COVID-19) via a severe cytokine cascade.
Cho KH, Kim JE, Nam HS, Kang DJ, Na HJ.
europepmc +4 more sources
Enhancing Wound Healing and Anti-Inflammatory Effects by Combination of CIGB-258 and Apolipoprotein A-I against Carboxymethyllysine Toxicity in Zebrafish: Insights into Structural Stabilization and Antioxidant Properties [PDF]
AntioxidantsCIGB-258 is known to exert anti-inflammatory activity via structural stabilization of apolipoprotein A-I (apoA-I) and functional enhancement of high-density lipoproteins (HDL) against acute toxicity of carboxymethyllysine (CML).
Kyung-Hyun Cho +6 more
doaj +4 more sources
Synergistic Anti-Inflammatory Activity of Lipid-Free Apolipoprotein (apo) A-I and CIGB-258 in Acute-Phase Zebrafish via Stabilization of the apoA-I Structure to Enhance Anti-Glycation and Antioxidant Activities. [PDF]
Int J Mol SciCIGB-258, a 3 kDa peptide from heat shock protein 60, exhibits synergistic anti-inflammatory activity with apolipoprotein A-I (apoA-I) in reconstituted high-density lipoproteins (rHDLs) via stabilization of the rHDL structure.
Cho KH +5 more
europepmc +4 more sources
A peptide derived from HSP60 reduces proinflammatory cytokines and soluble mediators: a therapeutic approach to inflammation [PDF]
Frontiers in Immunology, 2023 Cytokines are secretion proteins that mediate and regulate immunity and inflammation. They are crucial in the progress of acute inflammatory diseases and autoimmunity.
Maria del Carmen Domínguez-Horta +6 more
doaj +2 more sources
The treatment with Jusvinza reduces hyperinflammation and hypercoagulation in critical ill patients with COVID-19 [PDF]
Revista Cubana de Medicina Militar, 2021 Introduction: Infection with SARS-CoV-2 induces a prothrombotic state in patients, by the combination of hyperinflammatory response and hypoxia. In Cuba, the drug called Jusvinza, based on an immunomodulatory peptide, is used for the treatment of ...
Rafael Venegas Rodríguez +13 more
doaj +4 more sources
Péptido inmumodulador CIGB-258 para el tratamiento de pacientes graves y críticos con la COVID-19 [PDF]
Revista Cubana de Medicina Militar, 2020 Introducción: El CIGB-258 es un péptido inmunomodulador con propiedades antiinflamatorias. Objetivos: Establecer la frecuencia de dosis y el tiempo de tratamiento con el péptido CIGB-258, para pacientes críticos con la COVID-19.
Ariana García +14 more
core +3 more sources
CIGB-258 immunomodulatory peptide: a novel promising treatment for critical and severe COVID-19 patients [PDF]
, 2020 This study characterizes the first clinical application of CIGB-258 in COVID-19 patients. CIGB-258 is an immunoregulatory peptide, derived from the cellular heat shock protein 60 (HSP60).
A Garcia +15 more
core +2 more sources