Results 21 to 30 of about 92,889 (88)

Gene expression profiling unveils the temporal dynamics of CIGB-300-regulated transcriptome in AML cell lines

, 2023
Background Protein kinase CK2 activity is implicated in the pathogenesis of various hematological malignancies like Acute Myeloid Leukemia (AML) that remains challenging concerning treatment.
Mauro Rosales, George V. Pérez, Ailyn C. Ramón, Silvio E. Perea, Daniel Palenzuela, Ailenis Rosales, Dania Vázquez-Blomquist, Yasser Perera   +7 more
core   +1 more source

Antitumor efficacy, pharmacokinetic and biodistribution studies of the anticancer peptide CIGB-552 in mouse models

, 2014
Accumulation of the COMMD1 protein as a druggable pharmacology event to target cancer cells has not been evaluated so far in cancer animal models. We have previously demonstrated that a second-generation peptide, with cell-penetrating capacity, termed ...
Rodriguez, J.C., Brizaida Oliva, Oliva, B., Basaco, T., Iduna Fichtner, Calderon, C., Gomez, Y., Garay, H.E., Osvaldo Reyes, Pimentel, G., Markelova, M.R., Mendoza, O., Fichtner, I., Vallespi, M.G., Gilmara Pimentel, Hilda E. Garay, Garza, J., Ania Cabrales-Rico, Astrada, S., Carlos Calderón, Soledad Astrada, Juan C. Rodriguez, Iraida Sánchez, Maria Rivera Markelova, Cabrales-Rico, A., Tais Basaco, Julio Garza, Yolanda Gomez, Osmani Mendoza, Sanchez, I., Reyes, O., Bollati-Fogolín, M., Maribel G. Vallespí, Mariela Bollati-Fogolín   +33 more
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Investigaciones clínicas sobre COVID-19. Una breve panorámica

Anales de la Academia de Ciencias de Cuba, 2020
Desde inicios de la pandemia de COVID-19, los científicos del mundo trabajan incansablemente en el desarrollo de nuevas alternativas terapéuticas que propicien la prevención y el tratamiento de la enfermedad.
Tatiana Marañón Cardonne, Dianne Yurien Griñán Semanat, Sanlia Landazuri Llago, Enrique Juan Marañón Reyes   +3 more
doaj  

Mechanisms of Cellular Uptake, Intracellular Transportation, and Degradation of CIGB-300, a Tat-Conjugated Peptide, in Tumor Cell Lines

, 2016
CIGB-300 is a cyclic synthetic peptide that induces apoptosis in malignant cells, elicits antitumor activity in cancer animal models, and shows tumor reduction signs when assayed in first-in-human phase I trial in patients with cervical tumors.
Daniel F. Alonso (315989), Daniel E. Gomez (315988), Hernán G. Farina (1798567), Yasser Perera Negrin (1798570), Fernando R. Benavent Acero (1798561), Silvio E. Perea (1798564)   +5 more
core   +1 more source

The Antitumor Peptide CIGB-552 Increases COMMD1 and Inhibits Growth of Human Lung Cancer Cells [PDF]

, 2013
International audienceWe have demonstrated that the peptide L-2 designed from an alanine scanning of the Limulus-derived LALF32-51 region is a potential candidate for the anticancer therapy and its cell-penetrating capacity is an associated useful ...
Julio R. Fernández Massó, Delgado-Roche, Livan, Vallespí, Maribel G, Bollati-Fogolín, Mariela, Yelaine Tejeda, Reyes, Osvaldo, Hilda Garay, Osvaldo Reyes, Oliva Argüelles, Brizaida, Livan Delgado-Roche, Tejeda, Yelaine, Fernández Massó, Julio R, Astrada, Soledad, Garay, Hilda, Maribel G. Vallespí, Brizaida Oliva Argüelles, Mariela Bollati-Fogolín, Soledad Astrada   +17 more
core   +1 more source

LIPIcs, Volume 258, SoCG 2023, Complete Volume [PDF]

, 2023
LIPIcs, Volume 258, SoCG 2023, Complete ...
Gudmundsson, Joachim, Chambers, Erin W.
core   +1 more source

Abstract 1376: Antiangiogenic properties of the peptide CIGB-300

, 2010
CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in eukaryotes, constitutively active and has been implicated in multiple cellular functions, as well as in tumorigenesis and transformation.
Silvio Perea, Daniel E. Gomez, Hernán G. Farina, Roberto Gomez, Arielis Rodríguez, Daniel F. Alonso, Boris Acevedo Castro, Yasser Perera, Fernando Benavent Acero   +8 more
core   +1 more source

Dispositions réglementaires en matière de sécurité des barrages en France

, 1994
State control of installations built in water streams has been enforced in France for several centuries. It was extended to dams when they were built.
Le Trionnaire, Y., Goubert, A., Cottin, L., Royet, P.   +3 more
core  

CIGB-300 Anticancer Peptide Differentially Interacts with CK2 Subunits and Regulates Specific Signaling Mediators in a Highly Sensitive Large Cell Lung Carcinoma Cell Model

, 2022
Large cell lung carcinoma (LCLC) is one form of NSCLC that spreads more aggressively than some other forms, and it represents an unmet medical need. Here, we investigated for the first time the effect of the anti-CK2 CIGB-300 peptide in NCI-H460 cells as
Mauro Rosales, Paulo C. Carvalho, George V. Pérez, Ailyn C. Ramón, Silvio E. Perea, Yasser Perera, Vladimir Besada, Evelin Caballero, Arielis Rodríguez-Ulloa, Luis J. González, Rodrigo Soares Caldeira, Dania Vázquez-Blomquist, Daylen Aguilar, Ke Yang, Viviana Falcón   +14 more
core   +1 more source

Proteomic Profile Regulated by the Anticancer Peptide CIGB-300 in Non-Small Cell Lung Cancer (NSCLC) Cells

, 2016
CIGB-300 is a proapoptotic peptide-based drug that abrogates the CK2-mediated phosphorylation. This peptide has antineoplastic effect on lung cancer cells in vitro and in vivo.
Yassel Ramos (1974889), Boris E. Acevedo (2263090), Daniel F. Alonso (315989), Hernán Farina (2263084), Alexis Musacchio (189944), Arielis Rodríguez-Ulloa (2263069), Yairet García (2263078), Joem M. Serrano (2263081), Lila Castellanos-Serra (2263072), Gabriel Padrón (1974904), Vladimir Besada (1974907), Silvio E. Perea (1798564), Lázaro Betancourt (1974886), Jorge Fernández-de-Cossio (2263087), Jeovanis Gil (2105053), Yasser Perera (2263075), Aniel Sanchez (2258641), Luis J. González (1974898)   +17 more
core   +1 more source