Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer [PDF]
Cancers, 2019 Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. Many studies revealing alterations of ApoA-I during the development and progression of various types of cancer suggest that serum ApoA-I levels may ...
Elias Drakos, Drakos Elias
exaly +5 more sources
Multiple dysfunctions of two apolipoprotein A-I variants, apoA-I(R160L)Oslo and apoA-I(P165R), that are associated with hypoalphalipoproteinemia in heterozygous carriers [PDF]
Journal of Lipid Research, 1999 ApoA-I(R160L)Oslo and apoA-I(P165R) are naturally occurring apolipoprotein (apo) A-I variants that are associated with low HDL-cholesterol in heterozygous carriers.
Claus Langer +2 more
exaly +5 more sources
Association between Serum Concentrations of Apolipoprotein A-I (ApoA-I) and Alzheimer's Disease: Systematic Review and Meta-Analysis. [PDF]
Diagnostics (Basel), 2021 Background: A wealth of experimental and epidemiological evidence suggest that Apolipoprotein A-I (ApoA-I), the main protein constituent of high-density lipoprotein (HDL), may protect against Alzheimer disease (AD). To investigate this potential role, we conducted a meta-analysis of the published studies on the relationship between serum ApoA-I and AD ...
Zuin M +6 more
europepmc +7 more sources
The apoA-I mimetic peptide 4F protects apolipoprotein A-I from oxidative damage [PDF]
Chemistry and Physics of Lipids, 2019 High density lipoprotein (HDL) is prone to modification by the oxidizing and chlorinating agent hypochlorite anion (OCl-). Oxidation of apolipoprotein (apo) A-I, the major protein in HDL, reduces ABCA-1 mediated cholesterol efflux and other protective responses to HDL.
Geeta Datta +2 more
exaly +3 more sources
Trypsin Partially Cleaves Apolipoprotein A-I (ApoA-I) Precursor into Mature ApoA-I Hindering the Quantification of Naturally Occurring ApoA-I Proteoforms by Liquid Chromatography in Multiple Reaction Monitoring Mode Mass Spectrometry (LC-MRM-MS). [PDF]
J Am Soc Mass SpectromApolipoprotein A-I (ApoA-I), one of the most abundant proteins in plasma and the major protein component of high-density lipoprotein (HDL), is naturally found in several proteoforms; two of them are ProApoA-I and mature ApoA-I. These two proteoforms of ApoA-I coexist in biological samples and differ only in their N-terminal end. Virtually, the only way
Llorens-Cebrià C +7 more
europepmc +4 more sources
The 5A apolipoprotein A-I (apoA-I) mimetic peptide ameliorates experimental colitis by regulating monocyte infiltration. [PDF]
Br J Pharmacol, 2016 Background and PurposeNew therapies for inflammatory bowel disease (IBD) are highly desirable. As apolipoprotein (apo)A‐I mimetic peptides are beneficial in several animal models of inflammation, we hypothesized that they might be effective at inhibiting murine colitis.Experimental ApproachDaily injections of 5A peptide, a synthetic bihelical apoA‐I ...
Nowacki TM +11 more
europepmc +5 more sources
ABCA1 (ATP-Binding Cassette Transporter A1) Mediates ApoA-I (Apolipoprotein A-I) and ApoA-I Mimetic Peptide Mobilization of Extracellular Cholesterol Microdomains Deposited by Macrophages [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016 Objective— We examined the function of ABCA1 (ATP-binding cassette transporter A1) in ApoA-I (apolipoprotein A-I) mobilization of cholesterol microdomains deposited into the extracellular matrix by cholesterol-enriched macrophages.
Denis Sviridov +2 more
exaly +3 more sources
Carboxyl Terminus of Apolipoprotein A-I (ApoA-I) Is Necessary for the Transport of Lipid-free ApoA-I but Not Prelipidated ApoA-I Particles through Aortic Endothelial Cells [PDF]
Journal of Biological Chemistry, 2011 High density lipoproteins (HDL) and apolipoprotein A-I (apoA-I) must leave the circulation and pass the endothelium to exert their atheroprotective actions in the arterial wall. We previously demonstrated that the transendothelial transport of apoA-I involves ATP-binding cassette transporter (ABC) A1 and re-secretion of lipidated particles ...
Ohnsorg Pascale M +7 more
openaire +4 more sources
Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer [PDF]
Proceedings of the National Academy of Sciences, 2010 We examined whether reduced levels of Apolipoprotein A-I (apoA-I) in ovarian cancer patients are causal in ovarian cancer in a mouse model. Mice expressing a human apoA-I transgene had (i) increased survival (P< 0.0001) and (ii) decreased tumor development (P< 0.01), when compared with littermates, following injection of mouse ovarian epithelial ...
Feng, Su +15 more
openaire +2 more sources
Genome-wide Screen for Modulation of Hepatic Apolipoprotein A-I (ApoA-I) Secretion [PDF]
Journal of Biological Chemistry, 2013 Control of plasma cholesterol levels is a major therapeutic strategy for management of coronary artery disease (CAD). Although reducing LDL cholesterol (LDL-c) levels decreases morbidity and mortality, this therapeutic intervention only translates into a 25-40% reduction in cardiovascular events.
Rebecca R, Miles +15 more
openaire +2 more sources