Origin of Ciguateric Fish: Quantitative Modelling of the Flow of Ciguatoxin through a Marine Food Chain [PDF]
Toxins, 2022 To begin to understand the impact of food chain dynamics on ciguatera risk, we used published data to model the transfer of ciguatoxins across four trophic levels of a marine food chain in Platypus Bay, Australia.
Michael J. Holmes, Richard J. Lewis
doaj +5 more sources
Mouse N2a Neuroblastoma Assay: Uncertainties and Comparison with Alternative Cell-Based Assays for Ciguatoxin Detection [PDF]
Marine Drugs, 2023 The growing concern about ciguatera fish poisoning (CF) due to the expansion of the microorganisms producing ciguatoxins (CTXs) increased the need to develop a reliable and fast method for ciguatoxin detection to guarantee food safety. Cytotoxicity assay
Sandra Raposo-Garcia +6 more
doaj +3 more sources
Faster ciguatoxin extraction methods for toxicity screening [PDF]
Scientific ReportsCiguatera poisoning (CP) is a severe global public health problem caused by the consumption of seafood products contaminated with ciguatoxins (CTXs). The growing demand for seafood products requires high-throughput testing for CTX-susceptible seafood ...
Christopher R. Loeffler +1 more
doaj +5 more sources
Synthesis of the A-F Fragment of the Pacific Ciguatoxin CTX3C by Iterative Ring-Closing Metathesis and Tsuji-Trost Allylation. [PDF]
Chemistry, 2023 The fully functionalized A−F fragment of the Pacific ciguatoxin CTX3C has been synthesized from a derivative of D‐glucal, which serves as the B‐ring. Rings A and C were introduced to either side of ring B by ring‐closing diene and enyne metathesis (RCM).
Triantafyllakis M +4 more
europepmc +3 more sources
Modelling the Bioaccumulation of Ciguatoxins in Parrotfish on the Great Barrier Reef Reveals Why Biomagnification Is Not a Property of Ciguatoxin Food Chains [PDF]
ToxinsWe adapt previously developed conceptual and numerical models of ciguateric food chains on the Great Barrier Reef, Australia, to model the bioaccumulation of ciguatoxins (CTXs) in parrotfish, the simplest food chain with only two trophic levels.
Michael J. Holmes, Richard J. Lewis
doaj +3 more sources
Facile Synthesis of Molecularly Imprinted Ratiometric Fluorescence Sensor for Ciguatoxin P-CTX-3C Detection in Fish [PDF]
Foods, 2022 Ciguatoxin (CTX) detection methods are essential due to the serious hazard that bioaccumulation in fish and transmission along the food chain poses to human health.
Zhenke Qi +3 more
doaj +3 more sources
A General Food Chain Model for Bioaccumulation of Ciguatoxin into Herbivorous Fish in the Pacific Ocean Suggests Few Gambierdiscus Species Can Produce Poisonous Herbivores, and Even Fewer Can Produce Poisonous Higher Trophic Level Fish [PDF]
ToxinsWe adapt previous conceptual and numerical models of ciguateric food chains for the bioaccumulation of Pacific-ciguatoxin-1 (P-CTX-1) to a general model for bioaccumulation of P-CTX3C by parrotfish (Scarus frenatus, S. niger, and S.
Michael J. Holmes, Richard J. Lewis
doaj +3 more sources
Bimodal Cell Size and Fusing Cells Observed in a Clonal Culture of the Ciguatoxin-Producing Benthic Dinoflagellate Gambierdiscus (WC1/1) [PDF]
Toxins, 2022 Cells in a clonal culture of the WC1/1 strain of Gambierdiscus that produced ciguatoxin and maitotoxin-3 were observed to spontaneously fuse during the light phase of culture growth.
Michael J. Holmes, Richard J. Lewis
doaj +3 more sources
Synergistic Effect of Brevetoxin BTX-3 and Ciguatoxin CTX3C in Human Voltage-Gated Nav1.6 Sodium Channels. [PDF]
Chem Res Toxicol, 2023 Emerging marine biotoxins such as ciguatoxins and brevetoxins have been widely and independently studied as food pollutants. Their maximum levels in food components were set without considering their possible synergistic effects as consequence of their ...
Raposo-Garcia S +5 more
europepmc +2 more sources
Pacific Ciguatoxin-1 (P-CTX-1) in a Moray eel (<i>Gymnothorax javanicus</i>) Responsible for Ciguatera in Khanh Hoa Province, Viet Nam. [PDF]
Toxins (Basel)On 5 November 2020, a poisoning event involving four people by the consumption of moray eel occurred in Khanh Hoa Province, Viet Nam, with signs indicative of ciguatera.
Dao HV +12 more
europepmc +2 more sources