Synthesis of the A-F Fragment of the Pacific Ciguatoxin CTX3C by Iterative Ring-Closing Metathesis and Tsuji-Trost Allylation. [PDF]
Chemistry, 2023 The fully functionalized A−F fragment of the Pacific ciguatoxin CTX3C has been synthesized from a derivative of D‐glucal, which serves as the B‐ring. Rings A and C were introduced to either side of ring B by ring‐closing diene and enyne metathesis (RCM).
Triantafyllakis M +4 more
europepmc +3 more sources
Bimodal Cell Size and Fusing Cells Observed in a Clonal Culture of the Ciguatoxin-Producing Benthic Dinoflagellate Gambierdiscus (WC1/1) [PDF]
Toxins, 2022 Cells in a clonal culture of the WC1/1 strain of Gambierdiscus that produced ciguatoxin and maitotoxin-3 were observed to spontaneously fuse during the light phase of culture growth.
Michael J. Holmes, Richard J. Lewis
doaj +3 more sources
In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicity. [PDF]
Arch Toxicol, 2022 Ciguatoxins are marine compounds that share a ladder-shaped polyether structure produced by dinoflagellates of the genus Gambierdiscus and Fukuyoa, and include maitotoxins (MTX1 and MTX3), ciguatoxins (CTX3C) and analogues (gambierone), components of one
Raposo-García S +9 more
europepmc +4 more sources
Synergistic Effect of Brevetoxin BTX-3 and Ciguatoxin CTX3C in Human Voltage-Gated Nav1.6 Sodium Channels. [PDF]
Chem Res Toxicol, 2023 Emerging marine biotoxins such as ciguatoxins and brevetoxins have been widely and independently studied as food pollutants. Their maximum levels in food components were set without considering their possible synergistic effects as consequence of their ...
Raposo-Garcia S +5 more
europepmc +2 more sources
Pacific Ciguatoxin-1 (P-CTX-1) in a Moray eel (<i>Gymnothorax javanicus</i>) Responsible for Ciguatera in Khanh Hoa Province, Viet Nam. [PDF]
Toxins (Basel)On 5 November 2020, a poisoning event involving four people by the consumption of moray eel occurred in Khanh Hoa Province, Viet Nam, with signs indicative of ciguatera.
Dao HV +12 more
europepmc +2 more sources
Advances in Detecting Ciguatoxins in Fish [PDF]
Toxins, 2020 Ciguatera fish poisoning (CFP) is currently the most common marine biotoxin food poisoning worldwide, associated with human consumption of circumtropical fish and marine invertebrates that are contaminated with ciguatoxins.
Tibor Pasinszki +2 more
doaj +2 more sources
Rationally Designed Synthetic Haptens to Generate Anti-Ciguatoxin Monoclonal Antibodies, and Development of a Practical Sandwich ELISA to Detect Ciguatoxins [PDF]
Toxins, 2019 “Ciguatera” fish poisoning (CFP) is one of the well-known food poisoning caused by the ingestion of fish that have accumulated trace amounts of ciguatoxins (CTXs). CFP affects more than 50,000 individuals annually.
Takeshi Tsumuraya, Masahiro Hirama
doaj +2 more sources
Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells.
PLoS ONE, 2008 Ciguatoxins and brevetoxins are neurotoxic cyclic polyether compounds produced by dinoflagellates, which are responsible for ciguatera and neurotoxic shellfish poisoning (NSP) respectively. Recently, brevenal, a natural compound was found to specifically
César Mattei +9 more
doaj +2 more sources
Application of High-Resolution Mass Spectrometry for Ciguatoxin Detection in Fish from the Asia-Pacific Region. [PDF]
Toxins (Basel)Fish is a major source of protein in Asia–Pacific countries. Ciguatera fish poisoning (CFP), caused by consuming reef fish contaminated with ciguatoxins (CTXs), poses a significant health risk, affecting the neurological, gastrointestinal, and ...
Li X +7 more
europepmc +2 more sources
Toxins, 2021 Ciguatera poisoning is mainly caused by the consumption of reef fish that have accumulated ciguatoxins (CTXs) produced by the benthic dinoflagellates Gambierdiscus and Fukuyoa.
Yixiao Xu +8 more
doaj +2 more sources