Results 61 to 70 of about 13,123 (191)

Mitochondrial complex II and reactive oxygen species in disease and therapy

Redox Report, 2020
Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact ...
Katerina Hadrava Vanova, Michal Kraus, Jiri Neuzil, Jakub Rohlena   +3 more
doaj   +1 more source

Humoral immune responses in DBA mice immunized with type II collagen (CII) and complete Freund's adjuvant (CFA) and treated with 1-methyl-tryptophan (1-MT) or vehicle

, 2011
Copyright information:Taken from "Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice"http://arthritis-research.com/content/9/3/R50Arthritis Research & Therapy 2007;9(3):R50-R50 ...
Tamás Koreny (38676), Katalin Mikecz (511), Zoltán Szekanecz (38677), Tibor T Glant (512), John Varga (38678), Sándor Szántó (38675)   +5 more
core   +1 more source

Mechanism of Quasi‐Power‐Frequency Resonant Overvoltage Triggered by Multiple Lightning Strikes in High‐Voltage Alternating Current Systems Equipped With Shunt Reactor

High Voltage, EarlyView.
ABSTRACT This paper investigates the generation mechanism of quasi‐power‐frequency resonant overvoltage triggered by multiple lightning strikes in high‐voltage alternating current (HVAC) systems equipped with shunt reactors. Based on field measurements from a 500 kV AC system, equivalent and simplified circuit models have been established to analyse ...
Tao Liang, Tao Cui, Zhengxi Wang, Tongwei Guo, Xiaohui Wu, Hong Zeng, Jie Guo, Yanzhao Xie   +7 more
wiley   +1 more source

Tokenism in Context: Unpacking Token Women Directors in the Corporate Boardroom

Human Resource Management Journal, EarlyView.
ABSTRACT Tokenism in the corporate boardroom is a contemporary human resource management (HRM) issue for academics, practitioners and policy makers. This essay critiques the existing understanding of the concepts of tokens and tokenism in mainstream management and corporate governance scholarship within the particular context of women on corporate ...
Tanusree Jain, Harry J. Van Buren III, Deirdre Ahern   +2 more
wiley   +1 more source

Optineurin restrains CCR7 degradation to guide type II collagen-stimulated dendritic cell migration in rheumatoid arthritis

Acta Pharmaceutica Sinica B
Dendritic cells (DCs) serve as the primary antigen-presenting cells in autoimmune diseases, like rheumatoid arthritis (RA), and exhibit distinct signaling profiles due to antigenic diversity.
Wenxiang Hong, Hongbo Ma, Zhaoxu Yang, Jiaying Wang, Bowen Peng, Longling Wang, Yiwen Du, Lijun Yang, Lijiang Zhang, Zhibin Li, Han Huang, Difeng Zhu, Bo Yang, Qiaojun He, Jiajia Wang, Qinjie Weng   +15 more
doaj   +1 more source

Antigen-Specific Gene Therapy after Immunisation Reduces the Severity of Collagen-Induced Arthritis

Clinical and Developmental Immunology, 2013
Reestablishment of tolerance induction in rheumatoid arthritis (RA) would be an optimal treatment with few, if any, side effects. However, to develop such a treatment further insights in the immunological mechanisms governing tolerance are needed.
Tove Eneljung, Sara Tengvall, Pernilla Jirholt, Louise Henningsson, Rikard Holmdahl, Kenth Gustafsson, Inger Gjertsson   +6 more
doaj   +1 more source

Towards Credible GHG Reporting: The Role of GHG Assurance and Assurance Providers in Firm Valuation

Abacus, EarlyView.
The demand for greenhouse gas (GHG) emissions disclosures is rising globally; yet, the credibility of such information remains uncertain when assurance is not mandated. Drawing on a sample of firms from 43 countries, this study examines the role of GHG assurance and the choice of assurance provider in the market value effects of GHG emissions.
Sudipta Bose, Maria Balatbat, Wendy Green   +2 more
wiley   +1 more source

(a) Levels of induced antibodies against ^•OH-modified CII and native CII.

, 2013
(▴) and (▵) respectively represent immune and preimmune sera for •OH-modified collagen (CII-OH). While, (▪) and (□) represent immune and preimmune sera for native collagen (CII). ELISA plates were coated with CII-OH and native CII respectively (10 µg/ml).
Uzma Shahab (285629), Moinuddin (285630), Asif Ali (285640), Saheem Ahmad (285632), Safia Habib (285636), Kiran Dixit (285634), Khursheed Alam (285638)   +6 more
core   +1 more source

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

Mitochondrial respiration and characteristics of skeletal muscles in children with cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Skeletal muscles utilize numerous mitochondria for energy production needed during muscle contraction. Mitochondria produce this energy through the electron transport chain. After an injury such as ACL‐injury in typically developing children, there is a reduction in muscle mitochondrial respiration and content.
Sudarshan Dayanidhi, Guadalupe Meza, Ryan E. Kahn, Timothy Krater, Addison Barber, Tasos Karakostas, Craig J. Finlayson, Ishan Roy, Neeraj M. Patel, Jill E. Larson, Vineeta T. Swaroop   +10 more
wiley   +1 more source