Results 41 to 50 of about 43,139 (190)

Hysteresis and bistability in the succinate-CoQ reductase activity and reactive oxygen species production in the mitochondrial respiratory complex II

Redox Biology, 2020
The mitochondrial respiratory Complex II (CII) is one of key enzymes of cell energy metabolism, linking the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC).
Nikolay I. Markevich, Miliausha H. Galimova, Lubov N. Markevich   +2 more
doaj   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Hydroxyl radical modification of collagen type II increases its arthritogenicity and immunogenicity.

PLoS ONE, 2012
BackgroundThe oxidation of proteins by endogenously generated free radicals causes structural modifications in the molecules that lead to generation of neo-antigenic epitopes that have implications in various autoimmune disorders, including rheumatoid ...
Uzma Shahab, Saheem Ahmad, Moinuddin, Kiran Dixit, Safia Habib, Khursheed Alam, Asif Ali   +6 more
doaj   +1 more source

Ablation‐Immune Thermal Armor Via Microstructural‐Compatibility Design for Extreme Thermal Conditions

Advanced Science, EarlyView.
This study unveils a microstructural‐compatibility design strategy that integrates reactive melt infiltration with plasma spraying to fabricate carbon fiber‐reinforced ZrC‐SiC composites. The deliberate incorporation of SiC into the ZrC coating releases heat accumulation, suppresses detrimental lamellar ZrO2 formation, and reduces residual stress. This
Hongkang Ou, Lingxiang Guo, Bing Liu, Ziyi Yi, Yuyu Zhang, Jia Sun, Qiangang Fu   +6 more
wiley   +1 more source

Prepolymerization Enables On‐Demand Viscosity Tuning for Xolography of Soft Hydrogels

Advanced Science, EarlyView.
A facile in situ prepolymerization strategy enables on‐demand viscosity tuning across three orders of magnitude without external thickeners, transforming low‐viscosity resins into printable formulations for Xolography. The approach suppresses sedimentation, lowers curing dose, enables high‐fidelity support‐free fabrication, and produces advanced ...
Xichuan Li, Marcus Reuter, Linguangze Zhuo, Xueheng Dai, Camille Tribout, Nathaniel Corrigan, Jin Zhang, Cyrille Boyer   +7 more
wiley   +1 more source

(a) UV absorption spectral profile of CII (□), CII+H₂O₂ (○), CII+FeSO₄ (▵) and ^•OH-modified CII (▪).

, 2013
(b) Fluorescence emission spectra of native CII(—) and •OH-modified CII (---), Excitation wavelength was 265 nm.
Uzma Shahab (285629), Moinuddin (285630), Asif Ali (285640), Saheem Ahmad (285632), Safia Habib (285636), Kiran Dixit (285634), Khursheed Alam (285638)   +6 more
core   +1 more source

A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis

Frontiers in Immunology, 2018
BackgroundCollagen XI (CXI) is a heterotrimeric molecule with triple helical structure in which the α3(XI) chain is identical to the α1(II) chain of collagen II (CII), but with extensive posttranslational modifications.
Dongmei Tong, Dongmei Tong, Dongmei Tong, Erik Lönnblom, Anthony C. Y. Yau, Kutty Selva Nandakumar, Kutty Selva Nandakumar, Bibo Liang, Bibo Liang, Changrong Ge, Johan Viljanen, Lei Li, Mirela Bãlan, Lars Klareskog, Andrei S. Chagin, Andrei S. Chagin, Inger Gjertsson, Jan Kihlberg, Ming Zhao, Rikard Holmdahl, Rikard Holmdahl   +20 more
doaj   +1 more source

Carbon Ion Irradiation Downregulates Notch Signaling in Glioma Cell Lines, Impacting Cell Migration and Spheroid Formation

Cells, 2022
Photon-based radiotherapy upregulates Notch signaling in cancer, leading to the acquisition of the stem cell phenotype and induction of invasion/migration, which contributes to the development of resistance to therapy.
Vivek Kumar, Mohit Vashishta, Lin Kong, Jiade J. Lu, Xiaodong Wu, Bilikere S. Dwarakanath, Chandan Guha   +6 more
doaj   +1 more source

Vector‐Based SparseGPT: A Vector‐Based Sparsity Method for Large Language Model

Advanced Intelligent Systems, EarlyView.
Conventional pruning such as SparseGPT produces harmful accumulated errors through step‐by‐step weight editing. V‐SparseGPT prunes and updates target weights simultaneously to curb these errors for N:M structured sparsity. Block‐sparsity and layer‐parallel sparsity greatly boost pruning efficiency.
Junfei He, Mingxi Tan, Junchao Dong, Pengfei Ying   +3 more
wiley   +1 more source

cii Student Papers - 2024 [PDF]

In this collection of papers, we, the Research Group Critical Information Infrastructures (cii) from the Karlsruhe Institute of Technology, present seven selected student research articles contributing to the design, development, and evaluation of ...
Sunyaev, Ali, Erb, Yannick, Thiebes, Scott, Lins, Sebastian, Du, Guangyu, Renner, Maximilian, Toussaint, Philipp A., Research Group Critical Information Infrastructures (cii), Sunyaev, Ali;Du, Guangyu;Renner, Maximilian;Toussaint, Philipp A.;Thiebes, Scott;Lins, Sebastian;Erb, Yannick   +8 more
core   +1 more source