Results 51 to 60 of about 13,123 (191)

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

Prostate chronic inflammation type IV and prostate cancer risk in patients undergoing first biopsy set: Results of a large cohort study

Asian Journal of Urology, 2015
Objective: In prostate specimens, chronic inflammatory infiltrate (CII) type IV has been detected, but its association with prostate cancer (PCa) is controversial.
Antonio Benito Porcaro, Giovanni Novella, Matteo Balzarro, Guido Martignoni, Matteo Brunelli, Giovanni Cacciamani, Maria A. Cerruto, Walter Artibani   +7 more
doaj   +1 more source

Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity

Alzheimer’s Research & Therapy, 2023
Background Prevalence of overall cognitive impairment based on each participant’s performance across a neuropsychological battery is challenging; consequently, we define and validate a dichotomous cognitive impairment/no cognitive indicator (CII) using a
Megan E. O’Connell, Helena Kadlec, Lauren E. Griffith, Christina Wolfson, Geva Maimon, Vanessa Taler, Susan Kirkland, Parminder Raina   +7 more
doaj   +1 more source

Epileptic arousals: A neglected clinical entity

Epilepsia, EarlyView.
Abstract Objective Epileptic arousals (EAs) are seizures characterized solely by arousal from sleep. EAs are unrecognized in current seizure classifications. Their subtle semiology and inconsistently detectable ictal activity in scalp electroencephalography (EEG) complicate differentiation from physiological arousals (PAs). This study characterizes EAs
Lea Fisel, Nóra Pető, Sotirios Kalousios, Nicolas Zabler, Armin Brandt, Peter C. Reinacher, Dieter Riemann, Mohammad F. Khazali, Andreas Schulze‐Bonhage   +8 more
wiley   +1 more source

Developing and Examining the Psychometric Properties of Career Issues Inventory for Bipolar Disorder (CII-BD): An Instrument for Early Vocational Rehabilitation [PDF]

بهداشت و ایمنی کار, 2023
Introduction: Due to the lack of an instrument for measuring the career issues of those with bipolar disorder, the present study was conducted to develop and examine the psychometric characteristics of the Career Issues Inventory for Persons with Bipolar
Zeinab Rostami, Mohammad Reza Abedi, Parisa Nilforooshan   +2 more
doaj  

Squalius cii

, 2022
Squalius cii (Richardson, 1857) Figs. 2–3 Leuciscus cii Richardson 1857:375 (Type locality: Gemlek [Gemelik] River, north of Bursa, northwestern Turkey). Leuciscus cephaloides Battalgil 1942:298, Fig. 8 (Type locality: Armutlu, near Mudanya, north-western Turkey). Material examined. All from Turkey.
Bayçelebi, Esra, Turan, Davut, Aksu, İsmail, Freyhof, Jörg   +3 more
openaire   +1 more source

Deciphering the immunomodulatory mechanisms of Periplaneta americana L. extract CII-3: insight from integrated metabolomics and network pharmacology

Frontiers in Cell and Developmental Biology
BackgroundPeriplaneta americana L. is one of the most famous traditional Chinese medicines (TCMs), and CII-3 is the major bioactive extract of Periplaneta americana L.
Yilin Wang, Yilin Wang, Yilin Wang, Yingxiang Wu, Yingxiang Wu, Yingxiang Wu, Xi Liu, Xi Liu, Xi Liu, Zhiyan Lu, Zhiyan Lu, Zhiyan Lu, Tianqian Li, Tianqian Li, Tianqian Li, Yang Jin, Yan Wang, Yan Wang, Yan Wang, Jiali Zhu, Jiali Zhu, Jiali Zhu   +21 more
doaj   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

CryoBN‐PAGE: A Rapid and Cost‐Effective Method for the Analysis of Yeast Respiratory Complexes and Their Dynamic Organization

Yeast, EarlyView.
We present cryoBN‐PAGE, a method that enables blue native polyacrylamide gel electrophoresis analysis of mitochondrial respiratory complexes and supercomplexes directly from whole yeast cells using cryogenic milling. This approach eliminates the need for mitochondrial isolation, reducing time and cost while preserving native protein complexes.
Lizeth J. Camacho Lopez, Mazzen H. Eldeeb, Elliana G. Mohrhardt, Flavia Fontanesi   +3 more
wiley   +1 more source