Results 141 to 150 of about 53,999 (295)

Enigmatic Nodal and Lefty gene repertoire discrepancy: Latent evolutionary history revealed by vertebrate‐wide phylogeny

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Homology in vertebrate body plans is traditionally ascribed to the high‐level conservation of regulatory components within the genetic programs governing them, particularly during the “phylotypic stage.” However, advancements in embryology and molecular phylogeny have unveiled the dynamic nature of gene repertoires responsible for early ...
Shigehiro Kuraku
wiley   +1 more source

Molecular anatomy of emerging Xenopus left–right organizer at successive developmental stages

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Vertebrate left–right symmetry breaking is preceded by formation of left–right organizer. In Amphibian, this structure is formed by gastrocoel roof plate, which emerges from superficial suprablastoporal cells. GRP is subdivided into medial area, which generates leftward flow by rotating monocilia and lateral Nodal1 expressing areas,
Natalia Petri   +3 more
wiley   +1 more source

BMP4 regulates asymmetric Pkd2 distribution in mouse nodal immotile cilia and ciliary mechanosensing required for left–right determination

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Mouse nodal immotile cilia mechanically sense the bending direction for left–right (L–R) determination and activate the left‐side‐specific signaling cascade, leading to increased Nodal activity. Asymmetric distribution of Pkd2, a crucial channel for L–R determination, on immotile cilia has been reported recently. However, the causal
Takanobu A. Katoh   +5 more
wiley   +1 more source

Bioinformatics analysis of immune‐programmed cell death‐related genes in nasopharyngeal carcinoma

open access: yesEye &ENT Research, EarlyView.
Abstract Background Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor of the head and neck, characterized by a complex pathogenesis. Most newly diagnosed NPC patients are locally advanced, and 20%–30% of advanced NPC patients have poor immunotherapy results.
Hongqiang Chen   +3 more
wiley   +1 more source

Cilia incarnata. [PDF]

open access: bronze, 1976
Rubens Belfort, H. Bruce Ostler
openalex   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

open access: yesGlia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Hyperpolarized (HP) gas pulmonary MR ventilation images are typically quantified using ventilation defect percent (VDP); however, the test‐retest variability of VDP has not been systematically established in multi‐center trials. Herein, we perform a systematic review of the test‐retest literature on the variability of VDP, and similar metrics,
Vanessa M. Diamond   +15 more
wiley   +1 more source

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