Results 71 to 80 of about 164,456 (390)

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose.

PLoS ONE, 2016
We recently reported that olfactory sensory neurons in the dorsal zone of the mouse olfactory epithelium exhibit drastic location-dependent differences in cilia length.
Rosemary C Challis, Huikai Tian, Wenbin Yin, Minghong Ma   +3 more
doaj   +1 more source

A transgenic zebrafish for in vivo visualization of cilia

Open Biology, 2022
Cilia are organelles for cellular signalling and motility. Mutations affecting ciliary function are also associated with cilia-related disorders (ciliopathies).
Hongyu Zhang, Zhuoya Huang, Liuliu LV, Yuye Xin, Qian Wang, Feng Li, Lina Dong, Changxin Wu, Philip W. Ingham, Zhonghua Zhao   +9 more
doaj   +1 more source

Effectiveness and safety of baricitinib for juvenile idiopathic arthritis associated uveitis or chronic anterior antinuclear antibody positive uveitis

Arthritis Care &Research, Accepted Article.
Objectives Evaluate the efficacy and safety of baricitinib in paediatric patients with active JIA‐U or chronic anterior ANA‐positive uveitis, who had an inadequate response to MTX or bDMARDs. Methods JUVE‐BRIGHT was an open‐label, active‐controlled, Phase‐3 multicentre trial which utilized a novel design, including 1:1 randomization to an active ...
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue [PDF]

, 2013
BACKGROUND: Cilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and cellular movement; however, the roles of non-motile or primary cilia
Amber K O’Connor, Bradley K Yoder, Courtney J Haycraft, Erik B Malarkey, Mandy J Croyle, Nicolas F Berbari, O’Connor, Amber K, P Darwin Bell, Peter Hohenstein, Robert A Kesterson   +9 more
core   +2 more sources

Cilia at the crossroad: convergence of regulatory mechanisms to govern cilia dynamics during cell signaling and the cell cycle

Cell & Bioscience
Cilia are versatile, microtubule-based organelles that facilitate cellular signaling, motility, and environmental sensing in eukaryotic cells. These dynamic structures act as hubs for key developmental signaling pathways, while their assembly and ...
Lukáš Čajánek, Sindija Smite, Olha Ivashchenko, Martina Huranova   +3 more
doaj   +1 more source

Fluorescence imaging of beta cell primary cilia

Frontiers in Endocrinology, 2022
Primary cilia are slender cell-surface organelles that project into the intercellular space. In pancreatic beta cells, primary cilia coordinate a variety of cell responses including GPCR signaling, calcium influx, and insulin secretion, along with likely
Zipeng A. Li, Jung Hoon Cho, Louis G. Woodhams, Jing W. Hughes   +3 more
doaj   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Motile Cilia in Female and Male Reproductive Tracts and Fertility

Cells
Motile cilia are evolutionarily conserved organelles. In humans, multiciliated cells (MCCs), assembling several hundred motile cilia on their apical surface, are components of the monolayer epithelia lining lower and upper airways, brain ventricles, and ...
Dorota Wloga, Ewa Joachimiak, Anna Osinka, Salman Ahmadi, Sumita Majhi   +4 more
doaj   +1 more source

Propulsive nanomachines: the convergent evolution of archaella, flagella, and cilia.

FEMS Microbiology Reviews, 2020
Echoing the repeated convergent evolution of flight and vision in large eukaryotes, propulsive swimming motility has evolved independently in microbes in each of the three domains of life. Filamentous appendages-archaella in Archaea, flagella in Bacteria,
M. Beeby, J. Ferreira, P. Tripp, S. Albers, D. Mitchell   +4 more
semanticscholar   +1 more source