Results 181 to 190 of about 11,577 (216)
Functional genomic screen for modulators of ciliogenesis and cilium length [PDF]
Nature, 2010 Primary cilia are evolutionarily conserved cellular organelles that organize diverse signalling pathways. Defects in the formation or function of primary cilia are associated with a spectrum of human diseases and developmental abnormalities.
Joon Kim +2 more
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RFX2 is broadly required for ciliogenesis during vertebrate development [PDF]
Developmental Biology, 2012 In Caenorhabditis elegans, the RFX (Daf19) transcription factor is a major regulator of ciliogenesis, controlling the expression of the many essential genes required for making cilia.
Mei-I Chung +2 more
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Prostaglandin signaling in ciliogenesis and development
Journal of Cellular Physiology, 2021AbstractProstaglandin (PG) signaling regulates a wide variety of physiological and pathological processes, including body temperature, cardiovascular homeostasis, reproduction, and inflammation. Recent studies have revealed that PGs play pivotal roles in embryo development, ciliogenesis, and organ formation. Prostaglandin E2 (PGE2) and its receptor EP4
Daqing Jin, Tao P. Zhong
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Roles of the actin cytoskeleton in ciliogenesis
Journal of Cell Science, 2022ABSTRACT Primary cilia play a key role in the ability of cells to respond to extracellular stimuli, such as signaling molecules and environmental cues. These sensory organelles are crucial to the development of many organ systems, and defects in primary ciliogenesis lead to multisystemic genetic disorders, known as ciliopathies. Here, we
Huxley K. Hoffman, Rytis Prekeris
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Protocols to induce and study ciliogenesis
2023Primary cilia (PC) are sensory organelles that function as cellular antennas, transmitting signals between the extracellular and intracellular spaces in many vertebrate tissues. The cell generates and assembles PC through a highly regulated process called ciliogenesis.
Paula, Moreno-Cruz +4 more
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Nature Cell Biology, 2014
ABCC4 is a member of the ATP-binding cassette transporter family known to transport prostaglandin E2 and other molecules across cellular membranes. A mutation in ABCC4 is now shown to cause defects in ciliogenesis, revealing a role for prostaglandin signalling in regulating cilia dynamics.
Pascal, Barbry +1 more
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ABCC4 is a member of the ATP-binding cassette transporter family known to transport prostaglandin E2 and other molecules across cellular membranes. A mutation in ABCC4 is now shown to cause defects in ciliogenesis, revealing a role for prostaglandin signalling in regulating cilia dynamics.
Pascal, Barbry +1 more
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Ciliogenesis and ciliary abnormalities
Medical Electron Microscopy, 2000Cilia are motile processes extending from the basal bodies, playing important roles in the mucociliary clearance in the respiratory tract and the transport of the ovum from the ovary to the uterus in mammals. Ciliogenesis is divided into four stages: (1) duplication of centrioles; (2) migration of centrioles to the apical cell surface to become basal ...
H, Hagiwara +3 more
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Development of order during ciliogenesis
The Anatomical Record, 1968AbstractThis report consists of an electron microscope study of developing cilia in nasal epithelium of 15–18 day mouse embryos. As soon as recognizable cilia were observed, the typical 9 + 2 pattern of ciliary microtubule pairs was present. However, at this stage the intracellular spatial alignment of adjacent cilia, reflected in the adult by ...
D, Frisch, A I, Farbman
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Ciliogenesis in photoreceptor cells of the retina
Experimental Eye Research, 1981Ciliogenesis in the retinal photoreceptor of fetal, neonatal and adult ferrets has been investigated by electron microscopy. Ciliogenesis is described from the time (prenatal day 21) when a diplosome (two centrioles) is observed migrating toward the region of the external limiting membrane prior to eventual alignment beneath the apical plasma membrane ...
J V, Greiner +3 more
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Ciliogenesis: building the cell's antenna
Nature Reviews Molecular Cell Biology, 2011The cilium is a complex organelle, the assembly of which requires the coordination of motor-driven intraflagellar transport (IFT), membrane trafficking and selective import of cilium-specific proteins through a barrier at the ciliary transition zone.
Hiroaki, Ishikawa, Wallace F, Marshall
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