Results 51 to 60 of about 1,506 (183)

Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy

British Journal of Pharmacology, Volume 182, Issue 7, Page 1487-1507, April 2025.
Abstract Background and Purpose Sarcoplasmic reticulum Ca2+‐ATPase (SERCA2a) is impaired in heart failure. Phosphodiesterases (PDEs) are implicated in the modulation of local cAMP signals and protein kinase A (PKA) activity essential for cardiac function.
Zhenduo Zhu, Qiuyun Guan, Bing Xu, Sherif Bahriz, Ao Shen, Toni M. West, Yu Zhang, Bingqing Deng, Wei Wei, Yongsheng Han, Qingtong Wang, Yang K. Xiang   +11 more
wiley   +1 more source

First digital substation in TransGrid – Australia: a journey, business case, lessons

The Journal of Engineering, Volume 2018, Issue 15, Page 1135-1139, October 2018., 2018
IEC61850 has now been accepted ‘almost unequivocally’ as a preferred standard for substation communications.The extent of utilisation of this standard in a majority of installations around the world is at the ‘station bus’ level. It is foreseen that numerous benefits can be availed if the process values are digitised as close to the source as possible ...
Kevin Hinkley, Chirag Mistry
wiley   +1 more source

Prioritizing Generative Artificial Intelligence Co-Writing Tools in Newsrooms: A Hybrid MCDM Framework for Transparency, Stability, and Editorial Integrity

Mathematics
The rapid integration of generative artificial intelligence (AI) into newsroom workflows has transformed journalistic writing. Still, selecting reliable co-writing tools remains a multi-criteria challenge as it involves technical, ethical, and economic ...
Fenglan Chen, Bella Akhmedovna Bulgarova, Raman Kumar   +2 more
doaj   +1 more source

Cross‐pathway integration of cAMP signals through cGMP and calcium‐regulated phosphodiesterases in mouse striatal cholinergic interneurons

British Journal of Pharmacology, Volume 182, Issue 5, Page 1236-1253, March 2025.
Abstract Background and Purpose Acetylcholine plays a key role in striatal function. Firing properties of striatal cholinergic interneurons depend on intracellular cAMP through the regulation of Ih currents. Yet, the dynamics of cyclic nucleotide signalling in these neurons have remained elusive.
Ségolène Bompierre, Yelyzaveta Byelyayeva, Elia Mota, Marion Lefevre, Anna Pumo, Jan Kehler, Liliana R. V. Castro, Pierre Vincent   +7 more
wiley   +1 more source

Assessing Corporate Sustainability in Turkish Banks: WASPAS and ARAS Approaches in the Covid-19 and the Post-Covid-19 Era

Ekonomi, Politika & Finans Araştırmaları Dergisi
As sustainability shifts from a voluntary commitment to a structural necessity, particularly in emerging markets, the role of the banking sector in advancing sustainable development has become increasingly vital.
Özkan Çıtak, Ulaş Ünlü
doaj   +1 more source

Nicotine Impairs Smooth Muscle cAMP Signaling and Vascular Reactivity

Microcirculation, Volume 31, Issue 6, August 2024.
ABSTRACT Objective This study aimed to determine nicotine's impact on receptor‐mediated cyclic adenosine monophosphate (cAMP) synthesis in vascular smooth muscle (VSM). We hypothesize that nicotine impairs β adrenergic–mediated cAMP signaling in VSM, leading to altered vascular reactivity.
Navid Singhrao, Victor A. Flores‐Tamez, Yumna A. Moustafa, Gopireddy R. Reddy, Abby E. Burns, Kent E. Pinkerton, Chao‐Yin Chen, Manuel F. Navedo, Madeline Nieves‐Cintrón   +8 more
wiley   +1 more source

Sustainable Component-Level Prioritization of PV Panels, Batteries, and Converters for Solar Technologies in Hybrid Renewable Energy Systems Using Objective-Weighted MCDM Models

Energies
Data-driven prioritization of photovoltaic (PV), battery, and converter technologies is crucial for achieving sustainability, efficiency, and cost-effectiveness in the increasingly complex domain of hybrid renewable energy systems (HRES).
Swapandeep Kaur, Raman Kumar, Kanwardeep Singh   +2 more
doaj   +1 more source

Investigation of prevalence and antimicrobial resistance of Salmonella in pet dogs and cats in Turkey

Veterinary Medicine and Science, Volume 10, Issue 4, July 2024.
Salmonella prevalence was 5.73% (9/157) in dogs and 0.0% (0/191) in cats. Eight (8/9) isolates were cultured with the ISO method and 5 (5/9) isolates were cultured with the FDA method. Macroscopic results revealed that Salmonella agents had no effect on LAB. Three different serotypes (S. Enteritidis, S. Kentucky and S.
Merve Yildiz, Serpil Kahya Demirbilek
wiley   +1 more source

Evaluation of the Effects of Meal Type and Acid‐Reducing Agents on the Pharmacokinetics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist

Clinical Pharmacology in Drug Development, Volume 13, Issue 6, Page 677-687, June 2024.
Abstract Cilofexor is a nonsteroidal farnesoid X receptor agonist being developed in combination with firsocostat/semaglutide for the treatment of nonalcoholic steatohepatitis. This phase 1 study evaluated the effects of food and acid‐reducing agents (ARAs) on the pharmacokinetics of cilofexor (100‐ or 30‐mg fixed‐dose combination with firsocostat) in ...
Elijah J. Weber, Islam R. Younis, Lulu Wang, Deqing Xiao, William T. Barchuk, Ahmed A. Othman   +5 more
wiley   +1 more source

Decadal‐scale regional variability in monitoring efforts significantly influences fish diversity trends in the Euphrates and Tigris catchments, Türkiye

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 34, Issue 5, May 2024.
Abstract This study investigates the temporal and spatial distribution of species richness in the Turkish portions of the Euphrates and Tigris catchments in Mesopotamia, aiming to identify areas lacking sufficient research and inform future conservation and management efforts.
Esra Bayçelebi, Cüneyt Kaya, Irmak Kurtul, Davut Turan, Phillip Joschka Haubrock, Ismael Soto, Sadi Aksu, Ali Serhan Tarkan   +7 more
wiley   +1 more source