Results 231 to 240 of about 428,171 (265)

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Systematic Identification of Molecular Signatures Dictating Therapeutic Effects of Clinically First‐Line Chemotherapy Regimens for Human Gastric Cancer Patients Based on Organoid Model

MedComm, Volume 7, Issue 3, March 2026.
Chemotherapy is the mainstay in the treatment of advanced gastric cancer (GC); yet, GC showed diverse responses to first‐line chemotherapy regimens and the underlying molecular basis is still not clear. Here, we established a system that combined organoid‐based chemotherapy regimen screening and transcriptome‐based evaluation to identify underlying ...
Jingwei Yang, Shuyue Qi, Yuan Gao, Jiansen Lu, Lin Deng, Xinglong Wu, Yifei Zhao, Yun Liu, Yanpeng Ma, Jiagui Song, Lixiang Xue, Lu Wen, Wei Fu, Fuchou Tang, Xin Zhou   +14 more
wiley   +1 more source

Transcriptomic profiling of T cell exhaustion mechanisms in cervical cancer pathogenesis. [PDF]

Discov Oncol
Li C, Lin H, Zhang H.
europepmc   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

The utility of urinary liver-binding fatty acid protein levels as a promising biomarker for early detection of acute kidney injury following coronary angiography: a pre-post study at Suez Canal University Hospital. [PDF]

BMC Nephrol
Eladrosy MMT, Khedr MS, Saleh OM, Omar HH, Sultan BO.   +4 more
europepmc   +1 more source

Ultrasonography in General Practice: Insights From an Implementation Study in a Low‐Income Neighborhood of Amsterdam

Sonography, Volume 13, Issue 1, March 2026.
ABSTRACT Background Ultrasonography is increasingly being used in primary care settings, facilitated by technological advancements, reduced device‐related costs, and improved access to training and support. It holds particular promise for underserved communities, where barriers such as co‐pays or long waiting lists can limit access to diagnostic ...
Ralf E. Harskamp, Britt Soddemann genaamd Keute, Constantijn Pleiter, Jelle C. L. Himmelreich   +3 more
wiley   +1 more source

Pathophysiological Insights and Prognostic Value of the Triglyceride-Glucose Index in Patients with Chronic Total Occlusion. [PDF]

Anatol J Cardiol
Desai R, Prasad A, Nagarajan JS, Guddeti A, Mandalapu N, Patel DT, Shahnawaz W, Khatri S, Aleem A, Mohammed AS, Ghani MU.   +10 more
europepmc   +1 more source

Flopropione, a Cysteine Conjugate β-Lyase 1 Inhibitor, for Prevention of Cisplatin-Induced Nephrotoxicity: Protocol for a Randomized, Open-Label, Proof-of-Concept Phase 1 and 2a Trial.

JMIR Res Protoc
Koseki T, Kondo M, Fujigaki H, Kikuchi K, Oya Y, Kato H, Mizuno T, Tsuboi N, Kawada K, Goto Y, Hashimoto N, Imaizumi K, Kada A, Yabuuchi H, Saito K, Saya H.   +15 more
europepmc   +1 more source

Impact of Essential and Toxic Trace Elements on Cervical Premalignant Lesions. [PDF]

Biomedicines
Kocić J, Zečević N, Jagodić J, Mihajlović D, Dzuverović M, Pavlović N, Kotur-Stevuljević J, Manojlović D, Stojsavljević A.   +8 more
europepmc   +1 more source