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Human Skin Absorption and Metabolism of the Contact Allergens, Cinnamic Aldehyde, and Cinnamic Alcohol

Toxicology and Applied Pharmacology, 2000
trans-Cinnamaldehyde and trans-cinnamic alcohol have been commonly reported to cause allergic contact dermatitis (ACD) in humans. Cinnamaldehyde is a more potent skin sensitizer than cinnamic alcohol. It has been hypothesized that cinnamic alcohol is a "prohapten" that requires metabolic activation, presumably by oxidoreductase enzymes such as alcohol ...
Sharon A.M. Hotchkiss   +4 more
openaire   +3 more sources

THE MICROBIAL METABOLISM OF CINNAMIC ACID

Canadian Journal of Microbiology, 1964
A strain of Pseudomanas isolated from soil with cinnamic acid as a sole carbon source was found to be simultaneously adapted to the utilization of cinnamic acid and phenylpropionic acid. During growth on either of these compounds, o-hydroxyphenylpropionic acid and 2,3-dihydroxyphenylpropionic acid were produced in the culture medium. The organism, when
F. J. Simpson, E. R. Blakley
openaire   +3 more sources

Oxidative cyclization reaction of 2-aryl-substituted cinnamates to form phenanthrene carboxylates by using MoCl5.

Chemistry, 2014
The oxidative cyclization reaction of 2-aryl cinnamates and derivatives thereof can be easily performed with MoCl5 as the oxidant. This powerful reagent allows oxidative coupling reactions for which other reagents fail. The best results are obtained when
Kathrin Wehming   +3 more
semanticscholar   +1 more source

FeCl3 mediated intramolecular olefin-cation cyclization of cinnamates for the synthesis of highly substituted indenes.

Chemical Communications, 2013
Highly substituted indene derivatives were readily prepared in excellent yields with high regioselectivity under very mild reaction conditions by the FeCl3 mediated intramolecular olefin-cationic cyclization of cinnamates.
Dattatraya H. Dethe, Ganesh M Murhade
semanticscholar   +1 more source

The cinnamate/monolignol pathway

Phytochemistry Reviews, 2009
The cinnamate/monolignol pathway provides precursors for various phenylpropanoid compounds including lignins, lignans, neolignans, p-hydroxycinnamate esters, coumarins, suberins, flavonoids, stilbenes and so on. Therefore, the pathway plays the central role in plant secondary metabolism.
openaire   +2 more sources

Chlorogenic acids and other cinnamates - nature, occurrence, dietary burden, absorption and metabolism

, 2000
This paper summarises the occurrence in foods and beverages of the cinnamic acids, their associated conjugates and transformation products. Quantitative data are lacking for some commodities known to contain them, but it is clear that for many people ...
M. Clifford
semanticscholar   +1 more source

Fragrance material review on methyl cinnamate

Food and Chemical Toxicology, 2007
A toxicologic and dermatologic review of methyl cinnamate when used as a fragrance ingredient is presented.
J F Lalko   +5 more
openaire   +4 more sources

High-yield synthesis of bioactive ethyl cinnamate by enzymatic esterification of cinnamic acid

Food Chemistry, 2016
In this paper, Lipozyme TLIM-catalyzed synthesis of ethyl cinnamate through esterification of cinnamic acid with ethanol was studied. In order to increase the yield of ethyl cinnamate, several media, including acetone, isooctane, DMSO and solvent-free medium, were investigated in this reaction.
Na Chen   +4 more
openaire   +3 more sources

Absorption and emission properties of various substituted cinnamic acids and cinnamates, based on TDDFT investigation

, 2013
Absorption and emission properties of the hydroxy-, nitro-, and fluoro-group substituted at the ortho-, meta-, and para-positions of cinnamic acids (1A–9A) and cinnamates (1E–9E) were investigated using the density functional theory (DFT) and time ...
Malinee Promkatkaew   +4 more
semanticscholar   +1 more source

CN-assisted oxidative cyclization of cyano cinnamates and styrene derivatives: a facile entry to 3-substituted chiral phthalides.

Organic and biomolecular chemistry, 2012
The asymmetric dihydroxylation (AD) of o-cyano cinnamates and styrene derivatives leads to efficient construction of chiral phthalide frameworks in high optical purities.
R. Reddy, I. Kiran, A. Sudalai
semanticscholar   +1 more source

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