Results 31 to 40 of about 2,780 (190)

The role of CIP2A in oral squamous cell carcinoma [PDF]

Cancer Biology & Therapy, 2010
Commentary to:CIP2A expression and localization in oral carcinoma and dysplasiaJoseph Katz, Andrew Jakymiw, Monet K. Ducksworth, Carol M.
John R, Basile, Rakefet, Czerninski
openaire   +2 more sources

FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model [PDF]

, 2017
Background: Malignant mesothelioma (MM) is a very aggressive type of cancer, with a dismal prognosis and inherent resistance to chemotherapeutics. Development and evaluation of new therapeutic approaches is highly needed.
Agata Szymiczek, Andrea Napolitano, Carlotta Giorgi, David Larson, Giovanni Gaudino, Haining Yang, Harvey I. Pass, Hideki Furuya, Jiaming Xue, Laura Pellegrini, Michele Carbone, Mika Tanji, Paolo Pinton, Sandra Pastorino, Shuangjing Li, Yasutaka Takinishi   +15 more
core   +3 more sources

Prognostic value of CIP2A gene expression in adult Egyptian acute myeloid leukemia patients

Egyptian Journal of Medical Human Genetics, 2020
Background Protein phosphatase 2A (PP2A) functions as a tumor suppressor in many cancers. Cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibits PP2A proteolytic degradation of c-Myc and enhances cell growth and tumor formation in several tissues.
Roxan E. Shafik, Azza M. Ibrahim, Fadwa Said, Naglaa M. Hassan, Hanan E. Shafik, Hala A. Shokralla   +5 more
doaj   +1 more source

Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720 [PDF]

, 2014
We would like to thank Professor Andrew Hanby, Professor Valerie Speirs and Dr Thomas A Hughes for the breast cancer cell lines used in this study. This research was supported by the Faculty of Medicine and Surgery, University of Malta.Background: The
Baldacchino, Shawn, Borg, Nigel, Fenech, Anthony G., Grech, Godfrey, Petroni, Vanessa, Saliba, Christian   +5 more
core   +1 more source

Prognostic role of CIP2A expression in serous ovarian cancer [PDF]

British Journal of Cancer, 2011
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein expressed in several solid cancers. Our purpose was to study its role in serous ovarian cancer patients, and the association to clinicopathological variables and molecular markers.We collected retrospectively 562 consecutive serous ovarian cancer patients treated at the Helsinki ...
Ristimäki Ari, Leminen Arto, Haglund Caj, Böckelman Camilla, Lassus Heini, Butzow Ralf, Hemmes Annabrita, Ristimäki Ari, Leminen Arto, Haglund Caj, Böckelman Camilla, Lassus Heini, Bützow Ralf, Westermarck Jukka, Westermarck Jukka   +14 more
openaire   +4 more sources

Emerging roles of the CIP2A-TopBP1 complex in genome integrity. [PDF]

NAR Cancer, 2023
Abstract CIP2A is an inhibitor of the tumour suppressor protein phosphatase 2A. Recently, CIP2A was identified as a synthetic lethal interactor of BRCA1 and BRCA2 and a driver of basal-like breast cancers. In addition, a joint role of TopBP1 (topoisomerase IIβ-binding protein 1) and CIP2A for maintaining genome integrity during mitosis ...
Ummethum H, Li J, Lisby M, Oestergaard VH.   +3 more
europepmc   +5 more sources

Triple negative breast cancer: new perspectives for targeted therapies [PDF]

, 2015
Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors.
Caruso, Davide, Frati, Luigi, Minozzi, Marina, Papa, Anselmo, Rossi, Luigi, Tomao, Federica, Tomao, Silverio, Vici, Patrizia, Zaccarelli, Eleonora   +8 more
core   +1 more source

Exploring CIP2A modulators using multiple molecular modeling approaches

Journal of Biomolecular Structure and Dynamics, 2020
Like other human oncoproteins, Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) exerts cancer promoting function through interaction with other partner proteins, such as MYC and Protein Phosphatase 2A (PP2A). CIP2A regulates several MYC-independent and/or dependent gene expression programs.
Shovonlal Bhowmick, Kunal Roy, Achintya Saha   +2 more
openaire   +2 more sources

CIP2A expression and localization in oral carcinoma and dysplasia [PDF]

Cancer Biology & Therapy, 2010
Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy of the oral cavity resulting in severe morbidity and mortality. To date only few proteins have been suggested as potential biomarkers or targets for this type of cancer. Cancerous inhibitor of PP2A (CIP2A) is a protein expressed in epithelial tissues that stabilizes the oncogene c-Myc
Joseph, Katz, Andrew, Jakymiw, Monet K, Ducksworth, Carol M, Stewart, Indraneel, Bhattacharyya, Seunghee, Cha, Edward K L, Chan   +6 more
openaire   +2 more sources

CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway. [PDF]

Mol Med Rep
Bronchiolitis obliterans (BO) is a destructive fibrotic lung disease, which can be partly induced by 2,3‑butanedione [also known as diacetyl (DA)]; however, the mechanism underlying the effects of DA on BO is not clear. In the present study, a bioinformatics analysis was performed using DA‑treated or untreated lung tissues of rats, and it was observed ...
Zhou X, Zhao X, Li Y, Zhang B.
europepmc   +3 more sources