EBioMedicine, 2019 Background: Triple-negative breast cancer (TNBC) remains difficult to be targeted. SET and cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting inhibitors of protein phosphatase 2A (PP2A) and frequently overexpressed in
Chun-Yu Liu +10 more
doaj +1 more source
OCT4 Represses Inflammation and Cell Injury During Orchitis by Regulating CIP2A Expression
Frontiers in Cell and Developmental Biology, 2021 Octamer-binding transcription factor 4 (OCT4) and cancerous inhibitor of protein phosphatase 2A (CIP2A) are upregulated in testicular cancer and cell lines.
Ruifeng Zeng +8 more
doaj +1 more source
MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia [PDF]
, 2016 The SET (I2PP2A) oncoprotein is a potent inhibitor of protein phosphatase 2A (PP2A) that regulates many cell processes and important signaling pathways. Despite the importance of SET overexpression and its prognostic impact in both hematologic and solid ...
Allinquant +70 more
core +2 more sources
Sequence Expression of Supernumerary B Chromosomes: Function or Fluff? [PDF]
, 2019 B chromosomes are enigmatic heritable elements found in the genomes of numerous plant and animal species. Contrary to their broad distribution, most B chromosomes are non-essential. For this reason, they are regarded as genome parasites.
Akbari, Omar S +2 more
core +1 more source
Discovery of a Novel CIP2A Variant (NOCIVA) with clinical relevance in predicting TKI resistance in myeloid leukemias [PDF]
, 2021 This document is the Accepted Manuscript version of a published work that appeared in final form in [Clinical Cancer Research]. To access the final edited and published work see http://dx.doi.org/10.1158/1078-0432.CCR-20-3679Purpose: Cancerous inhibitor ...
Ammunét, Tea +13 more
core +2 more sources
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth [PDF]
, 2017 Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have achieved some clinical success, the inactivation of kinase signaling via stimulation of ...
Avelar, RA +44 more
core +1 more source
Predictive markers in cancer patient diagnosis, classification and prediction of therapy outcome using leukaemia as a model [PDF]
, 2014 The characterisation of the molecular mechanism of disease allows classification of patients into subtypes and potentially identifies specific targets for therapeutic intervention.
Baldacchino, Shawn +4 more
core +1 more source
Endogenous inhibitor proteins that connect Ser/Thr kinases and phosphatases in cell signaling. [PDF]
, 2012 Protein phosphatase activity acts as a primary determinant of the extent and duration of phosphorylation of cellular proteins in response to physiological stimuli. Ser/Thr protein phosphatase-1 (PP1) belongs to the PPP superfamily, and is associated with
Brautigan, David L, Eto, Masumi
core +2 more sources
Galectin-3 performance in histologic and cytologic assessment of thyroid nodules. A systematic review and meta-analysis [PDF]
, 2017 The literature on Galectin-3 (Gal-3) was systematically reviewed to achieve more robust information on its histologic reliability in identifying thyroid cancers and on the concordance between Gal-3 test in histologic and cytologic samples.
Crescenzi, Anna +4 more
core +1 more source
Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells [PDF]
, 2016 e Glasgow and Manchester Experimental Cancer Medicine Centres (ECMC), which are funded by CR-UK and the Chief Scientist’s Office (Scotland). We acknowledge the funders who have contributed to this work: MRC stratified medicine infrastructure award (A ...
A Hamilton +73 more
core +5 more sources