The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis [PDF]
, 2021 The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate DSB repair in favor of a tethering mechanism that stabilizes broken chromosomes until they are repaired in the subsequent cell cycle phases.
Mara De Marco Zompit +8 more
openaire +1 more source
Role of cancerous inhibitor of protein phosphatase 2A in the regulation of T-cell response [PDF]
, 2021 T helper (Th) cell subsets with distinct functions are a critical component of the adaptive immune system. Th17 cells secrete interleukin 17 (IL-17) and provide host defense against pathogens.
Khan, Mohd Moin
core
Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition
Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi +7 more
wiley +1 more source
The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer [PDF]
, 2021 BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination (HR). Identification of these adaptive mechanisms may provide therapeutic strategies to target tumors caused by the loss of these genes ...
Adam, Salomé +24 more
core +1 more source
Molecular Genetics &Genomic Medicine, Volume 13, Issue 8, August 2025.We present the most comprehensive synthesis to date of prenatal phenotypes associated with PPP2R1A‐related neurodevelopmental disorders. Ventriculomegaly, callosal anomalies, and heart defects are key prenatal indicators, supporting early diagnosis and informed genetic counseling.
Jiancheng Hu +5 more
wiley +1 more source
ER stress‐related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer
Molecular Oncology, 2018 Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and plays emerging roles in cancer. Activating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to contribute to ...
Chun‐Yu Liu +9 more
doaj +1 more source
Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells
Current Research in Immunology, 2020 Cancerous inhibitor of protein phosphatase 2A (CIP2A) is involved in immune response, cancer progression, and Alzheimer's disease. However, an understanding of the mechanistic basis of its function in this wide spectrum of physiological and pathological ...
Mohd Moin Khan +11 more
doaj +1 more source
Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer [PDF]
, 2018 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in cancer cells without causing damage to normal cells.
De Grève, Jacques +7 more
core +1 more source
Mechanism Analysis of LINC00665 and Its Peptides CIP2A-BP in Hepatocellular Carcinoma
Frontiers in Genetics, 2022 Background: More and more studies show that long non-coding RNAs (lncRNAs) have miniature open reading frames that can be translated into short peptides.
Yi-Ran Li +4 more
doaj +1 more source
Phosphatase Dysregulation in Cancer: Signaling Pathways and Therapeutic Opportunities
MedComm – Oncology, Volume 4, Issue 2, June 2025.Schematic depiction of the role of phosphatases in cancer, highlighting their involvement in proliferation, exosome secretion, and immunosuppression. The SHP2 crystal structure (PDB:5EHR) is shown as the representative phosphatase. ABSTRACT Phosphatases are increasingly recognized as critical regulators of cancer biology, with important roles in both ...
Maryam Jama +2 more
wiley +1 more source