Results 61 to 70 of about 156,781 (298)

Biodegradation and cytotoxicity of ciprofloxacin-loaded hydroxyapatite-polycaprolactone nanocomposite film for sustainable bone implants [PDF]

, 2015
Rajendran Nithya, Nachiappan Meenakshi Sundaram Department of Biomedical Engineering, PSG College of Technology, Coimbatore, India Introduction: In recent years there has been a steep increase in the number of orthopedic patients for many reasons.
Meenakshi Sundaram N, Nachiappan Meenakshi Sundaram, Nithya Rajendran, Nithya R   +3 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Adsorption characteristics of ciprofloxacin on the schorl: kinetics, thermodynamics, effect of metal ion and mechanisms

Journal of Water Reuse and Desalination, 2018
In this study, schorl was used as an effective adsorbent for ciprofloxacin removal from wastewater. The adsorption performance, mechanism and effect of metal ion on sorption were investigated. Adsorption capacity reached a maximum (8.49 mg/g) when the pH
Danyang Yin, Zhengwen Xu, Jing Shi, Lili Shen, Zexiang He   +4 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Removal of ceftriaxone and ciprofloxacin antibiotics from aqueous solutions using graphene oxide derived from corn cob [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Preliminary studies on the exploration of carbonaceous materials from agricultural waste and their use as adsorbents for antibiotic removal have shown the potential to address a new threat to human health due to antibiotic ...
. Rinawati, A. Rahmawati, D.R. Muthia, M.D. Imelda, F.H. Latief, S. Mohamad, A.A. Kiswandono   +6 more
doaj   +1 more source

Ciprofloxacin-Loaded Titanium Nanotubes Coated with Chitosan: A Promising Formulation with Sustained Release and Enhanced Antibacterial Properties

, 2023
Due to their high entrapment efficiency, anodized titanium nanotubes (TiO2-NTs) are considered effective reservoirs for loading/releasing strong antibiotics whose systemic administration is associated with diverse and severe side-effects.
Chaiyavat CHAIYASUT (4619875), Bahareh Farasati Far (9207785), soada asadi (14641058), Alireza Hadizadeh (14641208), bardia mortezagholi (14488361)   +4 more
core   +1 more source

Bioinspired Porphyrin‐Based Catalysts From Temporospatial Confined Frameworks for Ultrafast Removal of Sulfaclozine

Advanced Science, EarlyView.
We report the rational design of artificial photocatalysts with asymmetrically coordinated dual‐metal centers and a tailored microenvironment, broadly applicable strategy is established for the synthesis of multivariate zirconium‐based metal–organic frameworks, offering a platform for precisely tuning active‐site configurations to optimize ...
Yuxin Lu, Yu‐Hang Li, Zhiyi Sun, Fanke Tong, Zelin Li, Sheng Wang, Shangkun Pei, Yi Li, Xiyan Xu, Chong‐Chen Wang, Bo Wang, Xiang Li   +11 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Enzyme-Responsive Nanoparticles and Coatings Made from Alginate/Peptide Ciprofloxacin Conjugates as Drug Release System

Antibiotics, 2021
Infection-controlled release of antibacterial agents is of great importance, particularly for the control of peri-implant infections in the postoperative phase.
Yannick Bourgat, Carina Mikolai, Meike Stiesch, Philipp Klahn, Henning Menzel   +4 more
doaj   +1 more source