Results 121 to 130 of about 402,265 (407)

The Molecular Circadian Clock and Alcohol-Induced Liver Injury

Biomolecules, 2015
Emerging evidence from both experimental animal studies and clinical human investigations demonstrates strong connections among circadian processes, alcohol use, and alcohol-induced tissue injury.
Uduak S. Udoh, Jennifer A. Valcin, Karen L. Gamble, Shannon M. Bailey   +3 more
doaj   +1 more source

Role of Sleep Restriction in Daily Rhythms of Expression of Hypothalamic Core Clock Genes in Mice

Current Issues in Molecular Biology, 2022
Lack of sleep time is a menace to modern people, and it leads to chronic diseases and mental illnesses. Circadian processes control sleep, but little is known about how sleep affects the circadian system.
Weitian Li, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen   +4 more
doaj   +1 more source

Robustness of circadian clocks to daylight fluctuations: hints from the picoeucaryote Ostreococcus tauri [PDF]

, 2010
The development of systemic approaches in biology has put emphasis on identifying genetic modules whose behavior can be modeled accurately so as to gain insight into their structure and function.
A Goldbeter, A Goldbeter, Albert Goldbeter, AN Dodd, Benjamin Pfeuty, C Courties, C Troein, CS Pittendrigh, D Alabadi, D Gonze, D Rand, DA Rand, DB Forger, DGM Beersma, E Derelle, E Elowitz, E Hairer, F Corellou, F Geier, Florence Corellou, François-Yves Bouget, G Kurosawa, G Kurosawa, G Tiana, J Guckenheimer, J Moré, J Stricker, J Tomita, JC Leloup, JCW Locke, JCW Locke, JCW Locke, JD Salazar, L Ashall, L Rensing, LK Bognar, M Elowitz, M Merrow, M Moulager, MA Kramer, Marc Lefranc, MJ Chretiennot-Dinet, MN Zeilinger, N Barkai, NA Cookson, P Francois, P François, PE Morant, Pierre-Emmanuel Morant, Quentin Thommen, R Toth, S Panda, SR Taylor, TS Gardner, U Alon, W Mather, WW Wong, Y Ouyang, Y Shav-Tal   +58 more
core   +5 more sources

New Perspectives on Semiconducting Conjugated Oligomers for Neuromodulation in Hydra vulgaris

Advanced Materials Interfaces, EarlyView.
Semiconducting organic compounds, thiophene‐based, modify the rhythmic electrical activity of the cnidarian Hydra vulgaris acting on specific neuronal circuits. The ETE‐S trimer also forms electronically conducting wires in the living tissues of the animal.
Giuseppina Tommasini, Mariarosaria De Simone, Martina Blasio, Claudia Zenna, Angela Tino, Eleni Stavrinidou, Silvia Santillo, Claudia Tortiglione   +7 more
wiley   +1 more source

The circadian clock regulates the diurnal levels of microbial short‐chain fatty acids and their rhythmic effects on colon contractility in mice

Acta Physiologica, 2018
The microbiota shows diurnal oscillations that are synchronized by the host's circadian clock and feeding rhythms. Short‐chain fatty acids (SCFAs) produced by the microbiota are possible synchronizers of peripheral circadian clocks.
Anneleen Segers, Louis Desmet, T. Thijs, K. Verbeke, J. Tack, I. Depoortere   +5 more
semanticscholar   +1 more source

DNA damage and the circadian clock [PDF]

BioDiscovery, 2014
The role of the circadian clock has already been demonstrated for virtually all physiological processes, but it was only recently shown that cells were more sensitive to DNA damage at specific times of the day; that the peak of synthesis of mRNA and proteins of genes coding for products involved directly or indirectly in DNA repair was differentially ...
Chakarov,Stoyan, Petkova,Rumena, Russev,George Ch, Zhelev,Nikolai   +3 more
openaire   +4 more sources

Dual‐Crosslinked Betaine‐Based Amphiphilic Hydrogel as a Promising Vitreous Substitute: Anti‐Adhesion, Anti‐Fouling, and Anti‐Cell Proliferation

Advanced Science, EarlyView.
A novel multiple cross‐linked betaine‐type amphiphilic polymer hydrogels are developed via in situ free radical copolymerization. The resultant formation, named P(SBMA‐co‐AANa) hydrogel, functions as a vitreous substitute and demonstrates superior performance in optical properties, support capacity, and biocompatibility on a vitrectomized rabbit model.
Yuting Cai, Yun Tan, Jian Cao, Xiaoyuan Zhou, Xingyuan Li, Jianghua Li, Chuntai Liu, Yi Zhang, Yun Li   +8 more
wiley   +1 more source

Effect of H₂S on the circadian rhythm of mouse hepatocytes

Lipids in Health and Disease, 2012
Background Dysregulation of circadian rhythms can contribute to diseases of lipid metabolism. NAD-dependent deacetylase sirtuin-1(SIRT1) is an important hub which links lipid metabolism with circadian clock by its deacetylation activity depends on ...
Shang Zhanxian, Lu Chao, Chen Sifeng, Hua Luchun, Qian Ruizhe   +4 more
doaj   +1 more source

Rhythms of Locomotion Expressed by Limulus polyphemus, the American Horseshoe Crab: II. Relationship to Circadian Rhythms of Visual Sensitivity [PDF]

, 2008
In the laboratory, horseshoe crabs express a circadian rhythm of visual sensitivity as well as daily and circatidal rhythms of locomotion. The major goal of this investigation was to determine whether the circadian clock underlying changes in visual ...
Bedford, Lisa, Chabot, Christopher C., Watson, Winsor H., III   +2 more
core   +3 more sources

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source