Results 121 to 130 of about 109,508 (306)

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Light and circadian regulation of clock components aids flexible responses to environmental signals [PDF]

, 2014
The circadian clock measures time across a 24h period, increasing fitness by phasing biological processes to the most appropriate time of day. The interlocking feedback loop mechanism of the clock is conserved across species; however, the number of loops
Akman, Ozgur E, Dixon, Laura E, Hodge, Sarah K, Millar, Andrew J, Troein, Carl, van Ooijen, Gerben   +5 more
core   +2 more sources

SnapShot: Circadian Clock Proteins

Cell, 2008
The earth’s rotation about its axis generates predictable changes in light and temperature, which define the 24 hr day-night cycle. Organisms from bacteria to humans have evolved an internal timekeeper to anticipate these environmental changes. This timekeeper—the circadian clock—allows organisms to parse biological processes to the appropriate time of
Hamilton, Elizabeth E., Kay, Steve A.
openaire   +2 more sources

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Evolutionary relationships among barley and Arabidopsis core circadian clock and clock-associated genes [PDF]

, 2015
The circadian clock regulates a multitude of plant developmental and metabolic processes. In crop species, it contributes significantly to plant performance and productivity and to the adaptation and geographical range over which crops can be grown.
A Helfer, A Para, A Pokhilko, A Pokhilko, A Turner, A Zimmer, AB James, AB James, AH Paterson, AN Dodd, B Yu, BS Shin, BY Chow, C Campoli, C Campoli, C Campoli, C Li, C Lillo, C Troein, CR McClung, Cristiane P. G. Calixto, CT Hotta, D Alabadí, DA Matos, DB Fowler, DH Nagel, E Kolmos, E Ogiso, E Tauber, F Prosdocimi, F Valverde, F Yon, H Okamura, HR Song, J Cockram, J Felsenstein, JA Higgins, JC Locke, JC Schnable, JM Gendron, John W. S. Brown, JW Yu, K Holm, K Onai, K Tamura, K Tamura, KF Mayer, L Vallelian-Bindschedler, M Endo, M Gallego, M Iwamoto, M Klintenäs, M Martínez, M Murakami, M Serikawa, MA Larkin, MF Covington, MJ Haydon, MJ Moore, MN Zeilinger, N Nakamichi, N Nakamichi, N Saitou, N Suetsugu, N Takata, N Takata, P Lou, PA Pin, R Hayama, R Nitcher, R Poiré, RM Green, Robbie Waugh, RP Dunford, S Faure, S Faure, S Griffiths, S Nagasaka, S Stracke, S Zakhrabekova, SB Satbhai, SE Sanchez, SF Altschul, SF Boxall, SL Harmer, SL Harmer, SM Chaw, T Matsumoto, TA Miller, TP Michael, W Huang, W-Y Kim, X Wang, Y Kobayashi, Z Chen   +94 more
core   +3 more sources

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration [PDF]

, 2013
Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism.
Adam Q. Bauer, Benoit I. Giasson, David F. Wozniak, David M. Holtzman, David R. Weaver, Erik D. Herzog, Erik S. Musiek, Garret A. FitzGerald, Guangrui Yang, Jee Hoon Roh, Jilg, John B. Hogenesch, Joseph P. Culver, Joshua T. Dearborn, Kondratov, Kondratova, Kondratova, Krikor Dikranian, Laposky, Laura Qi, Miranda M. Lim, Reppert, Valnegri, Xilma Ortiz-Gonzalez, Yool Lee, Yu   +25 more
core   +2 more sources

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Circadian rhythm and its role in malignancy [PDF]

, 2010
Circadian rhythms are daily oscillations of multiple biological processes directed by endogenous clocks. The circadian timing system comprises peripheral oscillators located in most tissues of the body and a central pacemaker located in the ...
Sobia Rana, Saqib Mahmood
core   +1 more source

Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era

Advanced Science, EarlyView.
This review provides detailed information on modern cytoprotective strategies for ischemic stroke in the context of recanalization therapies. It derives their rationale based on contemporary knowledge of stroke pathophysiology and discusses the role of advanced imaging approaches as well as concepts for novel clinical trial designs.
Johannes Boltze, Marc Fisher
wiley   +1 more source