Results 121 to 130 of about 120,096 (334)

Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity

Cell Reports, 2019
Summary: Neurodegenerative diseases commonly involve the disruption of circadian rhythms. Studies indicate that mutant Huntingtin (mHtt), the cause of Huntington’s disease (HD), disrupts circadian rhythms often before motor symptoms are evident.
Fangke Xu, Elzbieta Kula-Eversole, Marta Iwanaszko, Alan L. Hutchison, Aaron Dinner, Ravi Allada   +5 more
doaj   +1 more source

A Bioinformatics Approach [PDF]

, 2015
By regulating the timing of cellular processes, the circadian clock provides a way to adapt physiology and behaviour to the geophysical time. In mammals, a light-entrainable master clock located in the suprachiasmatic nucleus (SCN) controls peripheral ...
Abreu, Monica, Childs, Liam, Fuhr, Luise, Herzel, Hanspeter, Lehmann, Robert, Leser, Ulf, Relógio, Angela, Thomas, Philippe   +7 more
core   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Circadian Rhythm in Yeast [PDF]

, 2012
Circadian rhythms are found in a variety of organisms and are involved in controlling activity of the organism. However, a circadian rhythm for yeast has not been discovered yet.
Borchert, Michael, Yablonowski, Jake
core   +1 more source

Robustness of circadian clocks to daylight fluctuations: hints from the picoeucaryote Ostreococcus tauri [PDF]

, 2010
The development of systemic approaches in biology has put emphasis on identifying genetic modules whose behavior can be modeled accurately so as to gain insight into their structure and function.
A Goldbeter, A Goldbeter, Albert Goldbeter, AN Dodd, Benjamin Pfeuty, C Courties, C Troein, CS Pittendrigh, D Alabadi, D Gonze, D Rand, DA Rand, DB Forger, DGM Beersma, E Derelle, E Elowitz, E Hairer, F Corellou, F Geier, Florence Corellou, François-Yves Bouget, G Kurosawa, G Kurosawa, G Tiana, J Guckenheimer, J Moré, J Stricker, J Tomita, JC Leloup, JCW Locke, JCW Locke, JCW Locke, JD Salazar, L Ashall, L Rensing, LK Bognar, M Elowitz, M Merrow, M Moulager, MA Kramer, Marc Lefranc, MJ Chretiennot-Dinet, MN Zeilinger, N Barkai, NA Cookson, P Francois, P François, PE Morant, Pierre-Emmanuel Morant, Quentin Thommen, R Toth, S Panda, SR Taylor, TS Gardner, U Alon, W Mather, WW Wong, Y Ouyang, Y Shav-Tal   +58 more
core   +5 more sources

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Supplementary Table S3 from Circadian Clock Gene <i>Bmal1</i> Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma

, 2023
Qingming Tang, Bo Cheng, Mengru Xie, Yatao Chen, Jiajia Zhao, Xin Zhou, Lili Chen   +6 more
openalex   +1 more source

Rapid analysis of circadian phenotypes in Arabidopsis protoplasts transfected with a luminescent clock reporter [PDF]

, 2016
The plant circadian clock allows the anticipation of daily changes to the environment. This anticipation aids the responses to temporally predictable biotic and abiotic stress.
Hansen, Louise L., Van Ooijen, Gerben
core   +1 more source

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source