Results 141 to 150 of about 402,265 (407)

The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle [PDF]

open access: yes, 2015
OBJECTIVE: Physical activity and circadian rhythms are well-established determinants of human health and disease, but the relationship between muscle activity and the circadian regulation of muscle genes is a relatively new area of research.
Abraham, Reimar   +12 more
core   +2 more sources

Combining PIM‐2 and PARP1 Inhibitors Induces MICA Expression on Multiple Myeloma Cells to Activate NK Cells through NKG2D Binding

open access: yesAdvanced Science, EarlyView.
The findings suggest that the combination of PIM‐2 and PARP1 inhibitors can induce MICA expression on MM cells, thereby activating NK cells through NKG2D binding. This process may restore NK cell function and serve as a potential therapeutic approach for MM patients. Abstract While immunogenic death in tumor cells activates specific anti‐tumor T cells,
Zhaoyun Liu   +6 more
wiley   +1 more source

Circadian Rhythms in the CNS and Peripheral Clock Disorders: Role of the Biological Clock in Cardiovascular Diseases

open access: yesJournal of Pharmacological Sciences, 2007
The cardiovascular diseases are closely related to circadian rhythm, which is under the control of the biological clock. Clock genes show circadian oscillation not only in the suprachiasmatic nucleus but also in peripheral tissues, suggesting the ...
Koji Maemura   +2 more
doaj  

Mutation of Arabidopsis SPLICEOSOMAL TIMEKEEPER LOCUS1 Causes Circadian Clock Defects [PDF]

open access: yes, 2012
The circadian clock plays a crucial role in coordinating plant metabolic and physiological functions with predictable environmental variables, such as dusk and dawn, while also modulating responses to biotic and abiotic challenges.
Brown, John WS   +5 more
core   +1 more source

Circadian Clock Control of Liver Metabolic Functions.

open access: yesGastroenterology, 2016
The circadian clock is an endogenous biological timekeeping system that synchronizes physiology and behavior to day/night cycles. A wide variety of processes throughout the entire gastrointestinal tract and notably the liver appear to be under circadian ...
H. Reinke, Gad Asher
semanticscholar   +1 more source

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

open access: yesAdvanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan   +16 more
wiley   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

open access: yesAdvanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen   +13 more
wiley   +1 more source

Biohybrid Computing with Proteinoids and Algae

open access: yesAdvanced Science, EarlyView.
We developed a novel biohybrid computing system by combining proteinoid microspheres with algae. The biological mixture creates spontaneous electrical oscillations. These oscillations can perform simple logic operations, such as AND, OR, NAND, and NOR gates. Environmental factors like temperature and pH affect how the system works.
Panagiotis Mougkogiannis   +1 more
wiley   +1 more source

The Plant Circadian Clock: From a Simple Timekeeper to a Complex Developmental Manager.

open access: yesCold Spring Harbor Perspectives in Biology, 2016
The plant circadian clock allows organisms to anticipate the predictable changes in the environment by adjusting their developmental and physiological traits. In the last few years, it was determined that responses known to be regulated by the oscillator
Sabrina E Sanchez, S. Kay
semanticscholar   +1 more source

Stem cells and the circadian clock

open access: yesDevelopmental Biology, 2017
The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24 h rhythms of behavioral and physiological processes. One intriguing observation is that stem cell homeostasis is subject to circadian clock regulation.
Weger, Meltem   +4 more
openaire   +6 more sources

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