Results 191 to 200 of about 301,259 (301)

KLF15 as a Metabolic Gatekeeper Linking Drug Metabolism, Toxicity, and Precision Therapeutics

iNew Medicine, EarlyView.
KLF15‐mediated metabolic preconditioning links metabolic state to drug disposition, therapeutic efficacy, and adverse effects, extending classical xenobiotic sensing toward precision pharmacology. ABSTRACT Krüppel‐like factor 15 (KLF15) is emerging as a metabolic‐state‐sensitive regulator of hepatic endobiotic and xenobiotic metabolism.
Shilin Li, Xue Li, Zhengding Su, Shuxin Han   +3 more
wiley   +1 more source

Circadian clock and its potential as a therapy for ischemic heart disease. [PDF]

Cell Commun Signal
Wang Y, Wang H, Liu N, Zhang J, Liu B.
europepmc   +1 more source

Sleep patterns during infancy and neurodevelopmental and behavioral outcomes in early childhood: A prospective cohort study

JCPP Advances, EarlyView.
Abstract Background Infant sleep is multidimensional, with sleep habits and sleep problems often co‐occurring and changing rapidly during early life. Evidence links infant sleep with later neurodevelopmental and behavioral outcomes, yet few studies have examined overall sleep patterns, their changes over time, and outcomes across multiple preschool ...
Wei Wei, Jun Zhang, Hui Wang
wiley   +1 more source

Rhythmic nuclear import mediated by importins regulates the Neurospora circadian clock. [PDF]

Genetics
Wang Z, Wang B, Bartholomai BM, Loros JJ, Dunlap JC.   +4 more
europepmc   +1 more source

The moderating role of anger rumination and self‐control in the day‐to‐day associations between irritability and sleep in male adolescents: An exploratory experience sampling method study

JCPP Advances, EarlyView.
Abstract Background Irritability is highly prevalent in adolescents and may be exacerbated by sleep disturbances, with sleep patterns undergoing significant changes during this developmental period. Reciprocally, poor sleep may generate an increase in anger dysregulation. This exploratory study investigates the day‐to‐day associations between sleep and
Julia Giovannini, Setareh Ranjbar, Jennifer Glaus, Ines Mürner‐Lavanchy, Lauriane Constanty, Kerstin Jessica Plessen, Sébastien Urben   +6 more
wiley   +1 more source

The Human Circadian Clock Protein Cryptochrome-1 Responds to Photochemistry by Conformational Changes. [PDF]

J Am Chem Soc
Jeibmann A, Qi M, Hellmich M, Godt A, Kottke T, Goett-Zink L.   +5 more
europepmc   +1 more source

Through Rested Eyes: The Relevance of Sleep for Dynamic Changes and Stable Differences in Employees' Stress Appraisals

Journal of Organizational Behavior, EarlyView.
ABSTRACT Even though stress appraisals determine employees' states and behaviors at work, knowledge of their antecedents is limited. This research project integrates sleep research into the transactional stress theory to explain how sleep, as a key factor shaping employees' resource availability, relates to employees' appraisals of their job demands ...
Jette Völker, Monika Wiegelmann, Miriam Schilbach   +2 more
wiley   +1 more source

CK2 and DBT promote temperature compensation of the <i>Drosophila</i> circadian clock via distinct pathways. [PDF]

iScience
Xia Y, Louis V, North LE, Emery P.
europepmc   +1 more source

Effects of oat protein on hematological parameters and metabolism in Wistar rats

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Diets rich in plant‐based proteins are becoming increasingly popular, but the safety of extracted oat (Avena sativa L.) protein in relation to cardiometabolic and endocrine risks remains unexplored. This study evaluated the safety of oat protein by analyzing anthropometric, hematological, biochemical, and histopathological ...
Gabriela Matte Bertoldi, Karine Raquel Uhdich Kleibert, Flávia Alessandra da Silva Räder, Alana Thais Gisch Andres, Luciana Mori Viero, Maria Andréia Inkelmann, José Antonio Gonzalez da Silva, Ivan Ricardo Carvalho, Christiane de Fátima Colet   +8 more
wiley   +1 more source

Brain circadian clock neurons drive fitness advantages in <i>Drosophila</i>. [PDF]

iScience
Aikawa S, Tamura S, Mimura M, Yoshii T.
europepmc   +1 more source