Results 191 to 200 of about 369,771 (309)

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

Porphyromonas gingivalis disrupts hippocampal circadian clock via PI3K/AKT pathway, exacerbating Alzheimer-like pathology. [PDF]

Alzheimers Dement
Huang C, Cai Q, Feng Z, Zhang C, Luo Z, Cheng X, Wu H.   +6 more
europepmc   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Oligomerization of PER2 as a dynamic mode of regulation of the mammalian circadian clock. [PDF]

Proc Natl Acad Sci U S A
Sanyal P, Sharma D, Viswan A, Crosby P, Narayanan V, Baumgartner J, Partch CL, Sekhar A.   +7 more
europepmc   +1 more source

Steroidopathies and hormonal imbalance in children and adolescents with autism spectrum disorder

JCPP Advances, EarlyView.
Abstract Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with a multifactorial etiology, many aspects of which remain unclear. Emerging evidence suggests a potential association between ASD and clinical manifestations resulting from hormonal imbalances, henceforth named “steroidopathies.” The present study aims to ...
Concetta de Giambattista, Patrizia Ventura, Samuele Cortese, Paolo Trerotoli, Alessandra Di Gioia, Lucia Margari   +5 more
wiley   +1 more source

Circadian clock regulation in lung health and disease: molecular mechanisms and therapeutic opportunities. [PDF]

EXCLI J
Baniya P, Puri S, Panth N, Thapa R, Gupta M, Singh SK, Bhatia R, Gupta G, Dua K, Paudel KR.   +9 more
europepmc   +1 more source

Toward an idiographic understanding of the role of sleep‐mood dynamics in adolescents' internalizing symptoms

JCPP Advances, EarlyView.
Abstract Background Adolescence is marked by increased vulnerability to sleep disturbances and mood disorders. Understanding how day‐to‐day changes in sleep and mood are linked within the same individual is crucial for clarifying sleep's role in emerging internalizing disorders. However, the extent to which an adolescent's fluctuations in sleep predict
Konstantin Drexl, Setareh Ranjbar, Sébastien Urben, Kerstin Jessica Plessen, Jennifer Glaus   +4 more
wiley   +1 more source

Biochemical mechanism of the mammalian circadian clock. [PDF]

FEBS Lett
Liu Y, Sancar A.
europepmc   +1 more source

Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals.

Cell Metabolism, 2017
Yaling Wu, Dingbin Tang, Na Liu, Wei Xiong, Huanwei Huang, Yang Li, Zhixiong Ma, Haijiao Zhao, Peihao Chen, Xiangbing Qi, E. E. Zhang   +10 more
semanticscholar   +1 more source

A randomized trial of I‐SLEEP: A patient education and empowerment intervention on inpatient sleep duration and medical sleep disruptions

Journal of Hospital Medicine, EarlyView.
Abstract Background Sleep is essential for recovery in hospitalized patients, yet frequent disruptions from medical care make rest difficult. Most prior efforts have focused on environmental modifications, often overlooking patients' role in advocating for their sleep.
Aashna Sunderrajan, John Cursio, Noah Mason, Maxx Byron, Maylyn Martinez, Nicola Orlov, Kristen L. Knutson, Babak Mokhlesi, Valerie G. Press, David O. Meltzer, Vineet M. Arora   +10 more
wiley   +1 more source