Aging Cell, Volume 24, Issue 4, April 2025.In this study, we describe a novel multi‐omics framework to train saliva‐based DNA methylation (DNAm) biomarkers that are reproducible and biologically interpretable. By leveraging a reliability dataset with replicates across tissues, we demonstrate knowledge transfer from blood DNAm to saliva DNAm data using DNAm proxies of blood proteins (EpiScores).
Lisa J. Schmunk +34 more
wiley +1 more source
Assessment of continuous positive airway pressure effect on the circadian clock signaling pathway in obstructive sleep apnea patients. [PDF]
Sci RepGabryelska A +7 more
europepmc +1 more source
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Cell, 2002 Satchidananda Panda +9 more
semanticscholar +1 more source
Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice
Aging Cell, Volume 24, Issue 5, May 2025.Over a 10‐week regimen, IMF significantly improved locomotor activity, motor coordination, and muscle strength compared to controls (p < 0.01). Resting‐state fMRI (rsfMRI) demonstrated that IMF modulates brain‐wide functional connectivity, enhancing communication between key brain regions.
Zhuang Liu +12 more
wiley +1 more source
Dietary Zinc Limitation Dictates Lifespan and Reproduction Trade‐Offs of Drosophila Mothers
Aging Cell, Volume 24, Issue 5, May 2025.Dietary metal ions significantly influence the lifespan and reproduction of Drosophila females. In this study, we show that not adding any of the metal ions to the diet adversely affects reproduction and lifespan. By contrast, food with no added Zn negatively impacts reproduction but not maternal lifespan, suggesting that female flies stop producing ...
Sweta Sarmah +5 more
wiley +1 more source
The cell-intrinsic circadian clock is dispensable for lateral posterior clock neuron regulation of <i>Drosophila</i> rest-activity rhythms. [PDF]
Neurobiol Sleep Circadian RhythmsGuerrero CYP +4 more
europepmc +1 more source
Aging Cell, Volume 24, Issue 5, May 2025.An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone +9 more
wiley +1 more source
Circadian clock regulation in soybean senescence: a transcriptome analysis of early and late senescence types. [PDF]
BMC GenomicsBasnet P +7 more
europepmc +1 more source
The Impact of Toll‐Like Receptor 5 on Liver Function in Age‐Related Metabolic Disorders
Aging Cell, EarlyView.Toll‐like receptor 5 (TLR5) deficiency accelerates age‐related metabolic disorders, leading to obesity, fatty liver, and cellular changes such as lipid accumulation in PMHs (hepatocytes) and activation of HSCs (hepatic stellate cells), which drive fibrosis.
Dong‐Hyun Kim +9 more
wiley +1 more source