Results 241 to 250 of about 136,810 (312)

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Disruption of the Circadian Rhythm Induces Acute Pancreatitis via Amino Acid Metabolism-Mediated Macrophage Infiltration. [PDF]

Cell Mol Gastroenterol Hepatol
Li H, Zhang X, He Z, Tong W, Liu W, Ma S, Lv J, Ling D, Wang Q, Wang J, Zheng J.   +10 more
europepmc   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm. [PDF]

Bone Res
Weng Y, Xiong J, Zhao Q, Tan Z.
europepmc   +1 more source

Sleep health of adults with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
Although many people with cerebral palsy (CP) are adults, most sleep research in CP focuses on children. As poor sleep can affect pain, mood, energy, daily functioning, and quality of life we reviewed what is currently known about the sleep health of adults with CP. We searched three major research databases (MEDLINE, Embase, and CINAHL) up to February
Deepika Nagabhushan, Caleb Kim, Daniel G. Whitney, Rita Ayyangar, Angeline Bowman, Sonia Sharma, Maxwell S. Barnish, Daniel Whibley   +7 more
wiley   +1 more source

Circadian rhythm disruption is related to self-diagnosis of mental illness. [PDF]

Discov Ment Health
Propper RE, Kang J, Sawyer M.
europepmc   +1 more source

Circadian rhythm of cortical and striatal adenosine receptors.

, 1993
C. FLORIO, TRAVERSA, UGO, R. V.E.R.T.U.A. CIRCADIAN RHYTHM OF CORTICAL AND STRIATAL ADENOSINE R.E.C.E.P.T.O.R.S. LIFE S.C.I., A. M. ROSATI   +3 more
core  

Test of the reward/circadian rhythm dysregulation model of risk for bipolar spectrum disorders at a micro time scale using multilevel moderated mediation. [PDF]

J Psychopathol Clin Sci
Smith LT, Maddox MA, Walsh RFL, Klugman J, Goel N, Alloy LB.   +5 more
europepmc   +1 more source

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source