A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness [PDF]
Advanced ScienceThe daily cycles of sleep and arousal are among the most prominent biological rhythms under circadian control. While the role of the suprachiasmatic nucleus (SCN) as the master circadian pacemaker is well‐established, the molecular and circuit mechanisms
Qiang Liu +6 more
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Histomorphometrical Analyses of the Mouse Suprachiasmatic Nucleus [PDF]
Bio-ProtocolThe mammalian central circadian clock resides in the suprachiasmatic nucleus (SCN) of the hypothalamus in the brain and is responsible for coordinating daily rhythms of biological processes spanning from gene expression to behavior.
Sophia Villanueva +5 more
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Altered light-dark phase-dependent behavioral responses and suprachiasmatic nucleus pathology in an α-synuclein rat model of Parkinson’s disease [PDF]
npj Parkinson's DiseaseDisruption of circadian rhythms is a key feature of neurodegenerative diseases and a non-motor feature of Parkinson’s disease, which significantly impairs health-related quality of life; yet, the underlying mechanisms are only partially understood ...
Hanna Weber +7 more
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The Suprachiasmatic Nucleus Regulates Anxiety-Like Behavior in Mice
Frontiers in Neuroscience, 2022 Individuals suffering from mood and anxiety disorders often show significant disturbances in sleep and circadian rhythms. Animal studies indicate that circadian rhythm disruption can cause increased depressive- and anxiety-like behavior, but the ...
Ryan W Logan +2 more
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Suprachiasmatic nucleus-wide estimation of oscillatory temporal dynamics. [PDF]
PLoS Computational BiologyThe suprachiasmatic nucleus (SCN), locus of a circadian clock, is a small nucleus of approximately 20,000 neurons that oscillate with a period of about 24 hours.
Yifan Yao +8 more
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Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum [PDF]
Translational PsychiatryThe circadian rhythm system consists of a master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks dispersed throughout other brain areas (including striatum, Str) as well as various tissues and organs ...
Xiaotao Liang +8 more
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Discrete photoentrainment of mammalian central clock is regulated by bi-stable dynamic network in the suprachiasmatic nucleus [PDF]
Nature CommunicationsThe biological clock synchronizes with the environmental light-dark cycle through circadian photoentrainment. While intracellular pathways regulating clock gene expression after light exposure in the suprachiasmatic nucleus are well studied in mammals ...
Po-Ting Yeh +6 more
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Quantitative measures of clock protein dynamics in the mouse suprachiasmatic nucleus extends the circadian time-keeping model [PDF]
The EMBO JournalThe suprachiasmatic nucleus (SCN) synchronises circadian rhythmicity (~24 h) across the body. The SCN cell-autonomous clock is modelled qualitatively as a transcriptional-translational feedback loop (TTFL), with heteromeric complexes of transcriptional ...
Nicola J Smyllie +9 more
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The role of the circadian system in maintaining homeostasis of the mammalian organism (literature review) [PDF]
Вестник Витебского государственного медицинского университета, 2022 One of the most significant factors that affect life on our planet is the cyclic change of day and night. For successful adaptation to and survival in the environment, various creatures from unicellular to mammals have developed mechanisms of ...
Е.S. Pashinskaya, V.V. Pabiarzhyn
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The suprachiasmatic nucleus [PDF]
Current Biology, 2018 Like it or not, your two suprachiasmatic nuclei (SCN) govern your life: from when you wake up and fall asleep, to when you feel hungry or can best concentrate. Each is composed of approximately 10,000 tightly interconnected neurons, and the pair sit astride the mid-line third ventricle of the hypothalamus, immediately dorsal to the optic chiasm (Figure
Andrew P, Patton, Michael H, Hastings
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