Results 261 to 270 of about 183,356 (348)

Different Mechanisms of Phase Delays and Phase Advances of the Circadian Rhythm in Rat Pineal N-Acetyltransferase Activity

, 1989
Helena Illnerová, Jiří Vaněčk, Klaus H. Hoffmann   +2 more
openalex   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin, Chiu‐Yi Ho, Gwo‐Ching Sun, Tzyy‐Yue Wong, Michael Hsiao, Ching‐Jiunn Tseng, Pei‐Wen Cheng   +6 more
wiley   +1 more source

Sex and Circadian Rhythm Dependent Behavioral Effects of Chronic Stress in Mice and Modulation of Clock Genes in the Prefrontal Cortex. [PDF]

Int J Mol Sci
Mingardi J, Giovenzana M, Nicosia N, Misztak P, Ieraci A, Musazzi L.   +5 more
europepmc   +1 more source

Opportunities of patient‐derived organoids in drug development

British Journal of Pharmacology, EarlyView.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals. [PDF]

Biology (Basel)
Mao W, Ge X, Chen Q, Li JD.
europepmc   +1 more source

Food Insecurity and Mental Health: A Moderated Mediation Analysis

Canadian Review of Sociology/Revue canadienne de sociologie, EarlyView.
ABSTRACT Extensive research has demonstrated the negative impact of food insecurity on mental health; however, the mediating and moderating mechanisms underlying this relationship remain underexplored. Using data from the 2022 National Health Interview Survey (N = 25,703), this study investigates whether sleep problems mediate the relationship between ...
Lei Chai
wiley   +1 more source

Seizure-related death exhibits a circadian rhythm independent of seizure timing or sleep in a mouse model of Dravet syndrome. [PDF]

J Physiol
Kreitlow BL, Novella-Maciel AT, Vázquez AMH, Buchanan GF.   +3 more
europepmc   +1 more source

The Pro‐Apoptotic Effect of Glucose Restriction in NSCLC via AMPK‐Regulated Circadian Clock Gene Bmal1

Cancer Science, EarlyView.
In this study we investigate the role of the core circadian gene BMAL1 in regulating mechanisms within non‐small cell lung cancer cells, revealing that circadian rhythm disruption may represent another significant factor triggering apoptosis. ABSTRACT The circadian clock is a crucial regulator of mammalian physiology, controlling daily oscillations in ...
Tao Wei, Ying Cheng, Jierong Ge, Manting Zhu, Hong Chen, Qing Feng   +5 more
wiley   +1 more source

Editorial: Biological and digital markers in sleep, circadian rhythm and epilepsy using artificial intelligence. [PDF]

Front Physiol
Sun H, Jefferson F, Parekh A, Oks M, Goldstein C.   +4 more
europepmc   +1 more source

Reconsidering the association between maternal Crohn's disease and offspring psychiatric outcomes

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Muhammad Armaghan Akhlaq, Hooria Ejaz, Mavia Habib, Malik Abdullah Rasheed, Mirza M. Hadeed Khawar   +4 more
wiley   +1 more source