Ras pathways help buffer biological timekeeping against metabolic perturbations
The FEBS Journal, EarlyView.Circadian clocks must be buffered (compensated) against conditions that could affect their rate (period). This figure shows rhythmic peaks of spore formation driven by the clock of the fungus Neurospora: The period is the same under different nutritional conditions in the wild‐type but not in a RasGEF mutant that disrupts an intracellular signaling ...
Patricia Lakin‐Thomas
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Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care
International Journal of Dermatology, EarlyView.Unlocking longevity in aesthetic dermatology: epigenetics, aging, and personalized care. ABSTRACT The concept of aging has evolved from being primarily attributed to genetic factors to recognizing the critical role of epigenetic mechanisms. Recent advancements, such as epigenetic clocks, have provided tools to assess biological age and offer insights ...
Diala Haykal +4 more
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Circadian rhythms of gut microbiota and plaque vulnerability: mechanisms and chrono-microbiota modulation interventions. [PDF]
Gut MicrobesZhai T +6 more
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Sketching T cell atlases in the single‐cell era: challenges and recommendations
Immunology &Cell Biology, EarlyView.Recent advances in single‐cell technologies have enabled the creation of T cell atlases, providing detailed maps of adaptive immunity across tissues, development and disease states. These atlases help uncover T cell diversity, functional states and disease mechanisms, aiding in the identification of therapeutic targets.
Itana Bojović +3 more
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Circadian rhythm genes and immune cell infiltration in myasthenia gravis: A comprehensive analysis. [PDF]
PLoS OneWang K +9 more
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Understanding Nurses' Needs Regarding Tailored, Evidence‐Based Sleep Education and Training
Journal of Advanced Nursing, EarlyView.ABSTRACT Aim Identify desired training content for shift‐working nurses to improve their sleep and fatigue. Design A descriptive qualitative design. Methods We recruited night shift nurses (N = 23) to provide feedback during virtual focus groups/interviews. Data collection occurred in the U.S. between March and June 2024.
Beverly M. Hittle +7 more
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The Effect of Dual Diagnosis of Substance Use Disorders on Circadian Rhythm and Sleep Quality in Patients with Bipolar Disorder. [PDF]
Noro Psikiyatr ArsYiğitbay B, İzci F.
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Conundrum and chances of diabetes management in the Western Pacific Region: A narrative review
Journal of Diabetes Investigation, EarlyView.The Western Pacific (WP) region, comprising countries with significant cultural and racial diversity, necessitates customized programs and community‐based management strategies. In this review, we present specific challenges and opportunities for diabetes management identified through a systematic review of the literature from the WP region, along with
Yerin Hwang, Hyunmin Lee, Moon‐Kyu Lee
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Sleep Disturbance in Parkinson's Disease: Consequences for the Brain and Disease Progression - A Narrative Review. [PDF]
Nat Sci SleepAnderson KN, Keogh MJ, Gosse L.
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Cellular responses to thermal stress and moderate oxygen limitation in juvenile lake trout
Journal of Fish Biology, EarlyView.Abstract Lake trout (Salvelinus namaycush) is an important food fish in northern communities, inhabiting cool, well‐oxygenated water, but climate change is reducing available habitat, with extended summer stratification of lakes creating an upper thermal barrier (~15°C) and lower dissolved oxygen (DO) boundary (4–7 mg L−1).
Alyssa M. Weinrauch +4 more
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