Longan flower water extract promotes sleep in mice via the serotonin–melatonin axis
Abstract BACKGROUND Longan (Dimocarpus longan) flower is an underutilized botanical byproduct rich in polyphenols with reported neuroprotective actions, yet its role in sleep regulation remains unclear. This study aimed to evaluate the sleep‐promoting effects of longan flower water extract (LFWE) and its underlying neurochemical mechanisms in vivo ...
Tzu‐Huan Hung +9 more
wiley +1 more source
Sleep disruption with aging in senescence-accelerated mice-prone 8 (SAMP8) mice and analysis of factors associated with age-related sleep fragmentation using RNA sequencing of the hypothalamus. [PDF]
Okamura K +6 more
europepmc +1 more source
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Self-assessment and rest-activity rhythm monitoring for effective bipolar disorder management: a longitudinal actigraphy study. [PDF]
Pfaffenseller B +6 more
europepmc +1 more source
ABSTRACT Objective We evaluated whether sleep disturbance moderates weight loss in breast cancer survivors. We hypothesized that poor sleep prior to behavioral weight loss (BWL) would be associated with less weight reduction than better sleep. Methods Women with prior stage 0‐III breast cancer with BMI ≥ 25 kg/m2 were randomized to BWL (n = 47) or self‐
Jennifer Y. Sheng +7 more
wiley +1 more source
Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications. [PDF]
Ren Q, Gu M, Fan X.
europepmc +1 more source
Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan +13 more
wiley +1 more source
Pathophysiological mechanisms of functional dyspepsia: a narrative review. [PDF]
Wang L +5 more
europepmc +1 more source
Summary Introduction Delirium is common in patients who are critically ill and associated with increased mortality and long‐term cognitive impairment. The objective of this study was to explore the barriers and facilitators to the use of existing ICU delirium identification tools and implementation of care protocols.
Roxanne M. Parslow +20 more
wiley +1 more source
Associations between sleep and circadian rhythm disruption and perinatal anxiety. [PDF]
Cox RC.
europepmc +1 more source

