Genetic basis of human circadian rhythm disorders. [PDF]
, 2013 Circadian rhythm disorders constitute a group of phenotypes that usually present as altered sleep-wake schedules. Until a human genetics approach was applied to investigate these traits, the genetic components regulating human circadian rhythm and sleep ...
Fu, Ying-Hui +3 more
core +2 more sources
Biological Rhythm and Chronotype: New Perspectives in Health
Biomolecules, 2021 The circadian rhythm plays a fundamental role in regulating biological functions, including sleep–wake preference, body temperature, hormonal secretion, food intake, and cognitive and physical performance.
Angela Montaruli +6 more
doaj +1 more source
Genetic insights on sleep schedules: this time, it's PERsonal. [PDF]
, 2012 The study of circadian rhythms is emerging as a fruitful opportunity for understanding cellular mechanisms that govern human physiology and behavior, fueled by evidence directly linking sleep disorders to genetic mutations affecting circadian molecular ...
Chong, SY Christin +2 more
core +1 more source
Current role and future perspectives of electroacupuncture in circadian rhythm regulation
Heliyon, 2023 In recent years, in-depth research on chronobiology has been conducted, and the circadian rhythm has become a new target for the treatment of diseases. Circadian rhythms are closely related to the normal physiological functions of organisms.
Min Yuan +5 more
doaj +1 more source
The role of melatonin in mood disorders [PDF]
, 2015 Melatonin (N-acetyl-5-methoxytryptamine) has been discovered as a hormone secreted by the pineal gland, even though it is also synthetized in various other organs, tissues, and cells.
Cavuto, Marilde +14 more
core +1 more source
Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice
Frontiers in Pharmacology, 2023 Stress may trigger sleep disorders and are also risk factors for depression. The study explored the melatonin-related mechanisms of stress-associated sleep disorders on a mouse model of chronic stress by exploring the alteration in sleep architecture ...
Tian-Ji Xia +12 more
doaj +1 more source
Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]
, 2015 The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA +2 more
core +2 more sources
Circadian rest-activity rhythms predict cognitive function in early Parkinson's disease independently of sleep [PDF]
, 2018 BACKGROUND: Cognitive impairment is a common and debilitating symptom of Parkinson's disease (PD), and its etiology is likely multifactorial. One candidate mechanism is circadian disruption. Although there is evidence of circadian abnormalities in PD, no
Cronin-Golomb, Alice +4 more
core +1 more source
Solving the mystery of human sleep schedules one mutation at a time. [PDF]
, 2013 Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui +2 more
core +1 more source
New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences
Frontiers in Neuroscience, 2021 Current approaches to quantify and diagnose sleep disorders and circadian rhythm disruption are imprecise, laborious, and often do not relate well to key clinical and health outcomes.
Bastien Lechat +7 more
doaj +1 more source