Results 41 to 50 of about 52,083 (330)

Bright Light Therapy in Parkinson's Disease: An Overview of the Background and Evidence

Parkinson's Disease, 2012
Sleep disorders are common in Parkinson's disease (PD) and seem to be strongly associated with depression. It has been suggested that sleep disorders as well as depression are caused by a disturbed circadian rhythm.
Sonja Rutten, Chris Vriend, Odile A. van den Heuvel, Jan H. Smit, Henk W. Berendse, Ysbrand D. van der Werf   +5 more
doaj   +1 more source

Integrating Assessment of Circadian Rhythmicity to Improve Treatment Outcomes for Circadian Rhythm Sleep-Wake Disorders: Updates on New Treatments. [PDF]

Curr Sleep Med Rep
Gloston GF, Ward KC, Rodriguez-Torres GC, Gamble KL, Thomas SJ.   +4 more
europepmc   +2 more sources

Circadian rhythms and sleep in bipolar disorder [PDF]

Bipolar Disorders, 2010
Murray G, Harvey A. Circadian rhythms and sleep in bipolar disorder.
Bipolar Disord 2010: 12: 459–472. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.Objective:  Biological rhythm pathways are highlighted in a number of etiological models of bipolar disorder, and the management of circadian instability appears in consensus ...
Murray, Greg, Harvey, Allison
openaire   +4 more sources

Solving the mystery of human sleep schedules one mutation at a time. [PDF]

, 2013
Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui, Hallows, William C, Ptáček, Louis J   +2 more
core   +1 more source

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]

, 2015
A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M, Bass, Joseph, Behn, Cecilia Diniz, Butler, Matthew P, Challet, Etienne, Czeisler, Charles, Depner, Christopher M, Elmquist, Joel, Franken, Paul, Grandner, Michael A, Hanlon, Erin C, Joyner, Michael J, Karatsoreos, Ilia, Keene, Alex C, Kern, Philip A, Klein, Samuel, Morris, Christopher J, Pack, Allan I, Panda, Satchidananda, Ptacek, Louis J, Punjabi, Naresh M, Sassone-Corsi, Paolo, Saxena, Richa, Scheer, Frank A, Scheer, Frank A, Seaquest, Elizabeth R, Thimgan, Matthew S, Van Cauter, Eve, Wright, Kenneth P   +28 more
core   +4 more sources

Acute Sleep-Wake Cycle Shift Results in Community Alteration of Human Gut Microbiome

mSphere, 2020
Disturbances of sleep and the underlying circadian rhythm are related to many human diseases, such as obesity, diabetes, cardiovascular disorders, and cognitive impairments. Dysbiosis of the gut microbiome has also been reported to be associated with the
Zhi Liu, Zhi-Yuan Wei, Junyu Chen, Kun Chen, Xuhua Mao, Qisha Liu, Yu Sun, Zixiao Zhang, Yue Zhang, Zhou Dan, Junming Tang, Lianhong Qin, Jian-Huan Chen, Xingyin Liu   +13 more
doaj   +1 more source

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. [PDF]

, 2018
Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction.
Colwell, Christopher S, Cutler, Tamara, Howland, David, Loh, Dawn H, Wang, Huei-Bin, Whittaker, Daniel S   +5 more
core   +1 more source

Sex Differences in Insomnia and Circadian Rhythm Disorders: A Systematic Review

Medicina
Insomnia and circadian rhythm disorders are increasingly common in modern society and lead to significant challenges for people’s health and well-being. Some studies suggests that men and women differ in neurohormonal secretion, biological processes, and
Evelina Pajėdienė, Viltė Urbonavičiūtė, Vita Ramanauskaitė, Lukas Strazdauskas, Ambra Stefani   +4 more
doaj   +1 more source

Circadian rest-activity rhythms predict cognitive function in early Parkinson's disease independently of sleep [PDF]

, 2018
BACKGROUND: Cognitive impairment is a common and debilitating symptom of Parkinson's disease (PD), and its etiology is likely multifactorial. One candidate mechanism is circadian disruption. Although there is evidence of circadian abnormalities in PD, no
Cronin-Golomb, Alice, Hu, Kun, Li, Peng, Stavitsky Gilbert, Karina, Wu, Jade Q.   +4 more
core   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source