Results 61 to 70 of about 63,496 (329)

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Circadian rhythm and aggressive behavior in community-dwelling schizophrenia patients testing a moderated mediation model

Frontiers in Psychiatry
BackgroundAggressive behavior in patients with schizophrenia poses significant challenges to community management. Although disruption of circadian rhythm is a recognized risk factor, the underlying mechanisms related to sleep disorders and social ...
Li Yuan Duan, Li Yuan Duan, Li Yuan Duan, Dong Mei Wu, Meng Lin Jiang, Yu-Tao Wang, Yu-Tao Wang, Zi-Yi Duan, Jia-Lu Xu, Rui-Tong Miao, Wei-Dong Lin, Yan Jiang, Yan Jiang   +12 more
doaj   +1 more source

Bidirectional Relationship Between Circadian Rhythm and Frailty

Nature and Science of Sleep, 2023
Yu Pan,* Zhu Qing Feng,* Yan Yuan,* Gui Ming Hu, Yi Jiang, Jiang Chuan Dong Department of Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China*This authors Contributed ...
Pan Y, Feng ZQ, Yuan Y, Hu GM, Jiang Y, Dong JC   +5 more
doaj  

Management of rapid eye movement sleep behavior disorder in patients with Parkinson's disease [PDF]

, 2016
Among all of the devastating effects that Parkinson’s disease (PD) has on an individual, sleep dysfunction is one that can have a profound effect on the entire family of the patient. The most potentially destructive of these sleep syndromes being that of
Jeffries, Michael
core   +1 more source

Protocol of the SOMNIA project : an observational study to create a neurophysiological database for advanced clinical sleep monitoring [PDF]

, 2019
Introduction Polysomnography (PSG) is the primary tool for sleep monitoring and the diagnosis of sleep disorders. Recent advances in signal analysis make it possible to reveal more information from this rich data source.
Arsenali, Bruno, Bergmans, Jan W. M., Fonseca, Pedro, Haakma, Reinder, Hoondert, Bertram, Krijn, Roy, Lauwerijssen, Coen, Leufkens, Tim R., Maass, Henning, Overeem, Sebastiaan, Pevernagie, Dirk, Pillen, Sigrid, van den Heuvel, Leonie, van Dijk, Johannes P., van Gilst, Merel M., van Sloun, Ruud J. G., Vandenbussche, Nele   +16 more
core   +2 more sources

Timing is everything: Expert opinion on researching epilepsy rhythms by the ILAE Task Force on Chronobiology

Epilepsia, EarlyView.
Abstract Recurrent seizures, the hallmark of epilepsy, are influenced by rhythms operating over multiple timescales. Chronobiology is the study of biological timing that aims to explain temporal patterns of events like seizures. Fueled by recent advances in genetics, computational modeling, and device engineering, the chronobiology of epilepsy is now a
Maxime O. Baud, Christophe Bernard, Birgit Frauscher, Philippa J. Karoly, Vikram R. Rao   +4 more
wiley   +1 more source

Plasticity of the intrinsic period of the human circadian timing system. [PDF]

PLoS ONE, 2007
Human expeditions to Mars will require adaptation to the 24.65-h Martian solar day-night cycle (sol), which is outside the range of entrainment of the human circadian pacemaker under lighting intensities to which astronauts are typically exposed. Failure
Frank A J L Scheer, Frank A J L Scheer, Kenneth P Wright, Richard E Kronauer, Charles A Czeisler   +4 more
doaj   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

Clocks & Sleep, 2020
Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles.
Chisato Kinoshita, Yayoi Okamoto, Koji Aoyama, Toshio Nakaki   +3 more
doaj   +1 more source

Mental health, sleep quality, and hormonal circadian rhythms in pregnant women with threatened preterm labor: a prospective observational study

BMC Pregnancy and Childbirth, 2023
Background Threatened preterm labor (TPL) is an important obstetrical challenge. Pregnant women with TPL may develop psychological and physical problems such as mental health disorders, sleep disturbance, and hormonal circadian rhythm disruption.
Xiao-Juan Wang, Xiao-Ting Li, Na Chen, Long Huang, Shui-Xiu Huang, Ting-Ting Chen, Gui-Hua Liu, Rong-Fang Hu   +7 more
doaj   +1 more source