Results 91 to 100 of about 1,017,685 (293)

Investigation on crack initiation life of helical gears in wind turbine gearbox based on temperature field

Forces in Mechanics
Gearboxes are critical mechanical components commonly used for wind turbines. This study develops a damage-coupled model to predict the crack initiation life of wind turbine gears, explicitly incorporating the effects of temperature fields and residual ...
Yong Yue, Xin Jin, Meilin Jiang, An Wu
doaj   +1 more source

Trajectory tracking control for a quadrotor UAV via extended state observer

Systems Science & Control Engineering, 2018
In this paper, the PD-type trajectory tracking controllevnr with the extended state observer (ESO) is proposed for the quadrotor unmanned aerial vehicle (UAV) to deal with the wind disturbance.
Wendong Gai, Jie Liu, Chengzhi Qu, Jing Zhang   +3 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Comparison of Optimum Balance Values For Different Coefficients of Spherical Aberration of Optical System Including Different Apertures

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
         The optimum balance values for different coefficient of spherical aberration (third and fifth degree also focal shift) were studied, the optical system includes different apertures (circle, ellipse, square and triangle) using point spread ...
Al. Badr Hassan, H. Mumtaz Ali, R. Faisal Rabee   +2 more
doaj  

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Asymptotic Stability Analysis of TSK Fuzzy PI Control System Using Circle Criterion

, 2015
In this paper, we study asymptotic stability of the Takagi-Sugeno-Kang (TSK) fuzzy PI control system using the circle criterion theorem. We first divide a TSK fuzzy PI controller into a memoryless nonlinear part and a linear dynamic unit, and merge the ...
Kim, H, Kim, J, Choi, OK, Lee, JS, Hyosin Kim, KIM, HYOSIN, Jin S. Lee, Ok-Kyu Choi, Jongkyoo Kim, LEE, JIN SOO   +9 more
core   +1 more source