Results 211 to 220 of about 1,017,685 (293)

Differential contributions of PTSD symptom clusters and their associations with resilience in traumatized individuals with a refugee background. [PDF]

Eur J Psychotraumatol
Amiri MA, Bjärtå A, Vernmark K, Demetry Y, Shahnavaz S, Meurling J, Andersson G.   +6 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Gradient-Based Efficient Optimization Method for Surface Sensor Arrays in Microseismic Source Mechanism Inversion. [PDF]

Sensors (Basel)
Kong Y, Yuan Y.
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

An empirical three-dimensional metric field for color space. [PDF]

J Vis
Koenderink JJ, van Doorn AJ, Braun DI, Gegenfurtner KR.   +3 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

HD-DRUM Rhythmic Training in Huntington's Disease: Feasibility, Motor, and Brain Microstructural Pilot Signals. [PDF]

Mov Disord Clin Pract
Laguna PL, Ioakeimidis V, Drew CJG, Pallmann P, Busse-Morris M, Watson GB, Schubert R, Rosser AE, Metzler-Baddeley C.   +8 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Large Language Models and Adverse Event Detection Within Immunotherapy Clinical Trials.

JAMA Netw Open
Elia MV, Friesner ID, Kwon D, Ni L, Sinha S, Ishiyama Y, Zack T, Bridge M, Fong L, Hong JC.   +9 more
europepmc   +1 more source

Study on strength criterion of progressive failure of structural loess under hydraulic action and true triaxial test. [PDF]

PLoS One
Fang J, Luo A, Chen C, Fu W, Zhao Z.
europepmc   +1 more source