Results 111 to 120 of about 1,747,809 (284)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Global search method for solving Malfatti’s four-circle problem
Известия Иркутского государственного университета: Серия "Математика", 2016 We consider Malfatti’s problem formulated 200 years ago. In the beginning, Malfatti’s problem was supposed to be solved in a geometric construction way. In 1994, it was done by Zalgaller and Los for the original Malfatti’s problem using so-called greedy ...
R. Enkhbat, M. Barkova
doaj
A Progressive Search Method for Roundness Evaluation Based on Minimum Zone Criterion
MicromachinesWith the rapid development of micro-machining technology, the feature size of object parts becomes smaller whilst the roundness tolerance must be critically verified at sub-micrometers or nanometers.
Jian Mei +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Long-range DCS-Anya trajectory planning algorithm considering initial and terminal state constraints
Xibei Gongye Daxue XuebaoIn long-range Earth surface planning scenarios, the curvature of the spherical surface significantly influences trajectory planning. Addressing the problem of long-range spherical trajectory planning with initial and end-state constraints, a DCS-Anya ...
LIU Siyu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Circle-circle intersection. A universal method for solving typical surveying problems
Applied GeomaticsAbstractThe research problem of the article is to devise a universal mathematical procedure for calculating point coordinates from typical planar surveying measurements. The proposed solution involves calculating the intersection points of two circles with radii equal to the measured distances (the distance-distance intersection problem).
openaire +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source