Results 81 to 90 of about 17,391 (302)

Polynomial-time approximation schemes for circle and other packing problems [PDF]

, 2017
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)We consider the problem of packing a set of circles into a minimum number of unit square bins.
Pedrosa, Lehilton L. C., Wakabayashi, Yoshiko, Sviridenko, Maxim, Miyazawa, Flavio K., Schouery, Rafael C. S.   +4 more
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Computational Circle Packing: Geometry and Discrete Analytic Function Theory [PDF]

, 2010
Geometric Circle Packings are of interest not only for their aesthetic appeal but also their relation to discrete analytic function theory. This thesis presents new computational methods which enable additional practical applications for circle packing ...
Orick, Gerald Lee
core   +1 more source

Revisiting the Hexagonal Lattice: On Optimal Lattice Circle Packing [PDF]

, 2010
In this note we give a simple proof of the classical fact that the hexagonal lattice gives the highest density circle packing among all lattices in R2.
Fukshansky, Lenny, Lenny Fukshansky
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Installation of Smog-Free Towers Using Novel Real Coded Genetic Algorithm

IEEE Access
The circle packing problem involves finding the best way to place non-overlapping circles within a given space, while the smog-free tower installation problem aims to minimize the exposure of residents to secondhand smog by identifying the optimal tower ...
Yogesh Kumar, Kusum Deep, Atulya K. Nagar   +2 more
doaj   +1 more source

Heterogeneous UAV Cells: An Effective Resource Allocation Scheme for Maximum Coverage Performance

IEEE Access, 2019
This paper develops an effective approach for the 3D deployment of a heterogeneous set of unmanned aerial vehicles (UAVs) acting as aerial base stations that provide maximum wireless coverage for ground users in a given geographical area. This problem is
Nima Namvar, Abdollah Homaifar, Ali Karimoddini, Behrouz Maham   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Circle Packing Algorithm [PDF]

. A circle packing is a configuration P of circles realizing a specified pattern of tangencies. We describe an efficient algorithm for computing the radii of packings in euclidean and hyperbolic geometry, discuss its performance, and illustrate some ...
Charles R. Collins, Kenneth Stephenson
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