Results 61 to 70 of about 467,200 (296)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Resonance Overlap and Hill Stability Criteria Revisited [PDF]

, 2015
We review the orbital stability of the planar circular restricted three-body problem, in the case of massless particles initially located between both massive bodies.
Beaugé, C., Correa-Otto, J. A., Ramos, X. S.   +2 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Własności Mechaniczne Kilku Modeli Gruntów

Engineering Transactions, 1964
This paper is devoted to the description and analysis of some results concerning problems of granular bodies representing continuous bodies. The test have been performed by means of samples composed of parallel glass rods of circular or polygonal cross ...
J. Biarez
doaj  

Linear Polarization Variations and Circular Polarization Are Common among Airless Bodies

The Planetary Science Journal
Using the POLISH2 polarimeter at the Lick Observatory Shane 3 m and Nickel 1 m telescopes, we discover rotation-phase-locked variations in linear polarization to be common among asteroids and a near-Earth object (NEO) in a clear, 383−720 nm bandpass ...
Sloane J. Wiktorowicz, Amanda J. Bayless, Larissa A. Nofi   +2 more
doaj   +1 more source

An alternative origin for debris rings of planetesimals

, 2012
Core Accretion, the most widely accepted scenario for planet formation, postulates existence of km-sized solid bodies, called planetesimals, arranged in a razor-thin disc in the earliest phases of planet formation.
Alibert, Armitage, Aumann, Baruteau, Bernstein, Boley, Boley, Boley, Boss, Boss, Bottke, Cha, Cuzzi, Donnison, Dunham, Forgan, Gingold, Goldreich, Gomes, Helled, Hellyer, Ida, Ida, Ilee, Johansen, Kenyon, Larson, Lucy, Machida, Mayer, McCrea, Michael, Mizuno, Monaghan, Morbidelli, Nayakshin, Nayakshin, Nayakshin, Nayakshin, Nayakshin, Nayakshin, Nayakshin, Nesvorný, Nesvorný, Nesvorný, Nesvorný, Perri, Pollack, Rafikov, Rafikov, Rafikov, Rees, Rice, Safronov, Sergei Nayakshin, Seung-Hoon Cha, Shapiro, Springel, Springel, Stevenson, Stewart, Tanaka, Vorobyov, Vorobyov, Vorobyov, Weidenschilling, Wyatt, Wyatt, Wyatt, Youdin, Youdin, Zubovas, Zuckerman   +72 more
core   +1 more source

Gravitational waves in the circular restricted three body problem

Classical and Quantum Gravity
Abstract The prospect of unprecedented high-quality data of gravitational waves in the upcoming decades demands a theoretical effort to optimally study and analyze the signals that next generation detectors will provide. Here we study the gravitational wave emission and related dynamics during the inspiralling phase of the Circular ...
Mikel Martin Barandiaran, Sachiko Kuroyanagi, Savvas Nesseris   +2 more
openaire   +4 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source