Results 91 to 100 of about 1,297,074 (297)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
A high-gain omnidirectional satellite antenna technique Final report [PDF]
High gain omnidirectional satellite system design, using planar and circular multiple beam arrays and solid state ...
Chadwick, G. G., Hill, J. E., Kerr, P.
core +1 more source
Circular Design and Functionalized Upcycling of Waste Commodity Polystyrene via C-H Activation Using Microwave-Assisted Multicomponent Synthesis. [PDF]
Polymers (Basel), 2023 Shetranjiwalla S, Cislak C, Scotland KM.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
BuildingsAs Hong Kong faces increasing pressure on resources and environmental sustainability, there is a growing need to shift towards circular building practices.
Ericson K. S. Lau +3 more
doaj +1 more source
Circular Materials and Circular Design-Review on Challenges Towards Sustainable Manufacturing and Recycling. [PDF]
Circ Econ Sustain, 2022 Dumée LF.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Limestone surface weathering cycles as the basis of circular architectural design
ARTEKS : Jurnal Teknik ArsitekturThis study explores the process of limestone weathering as the basis of a circular architectural design method. The natural process of limestone weathering enable neutralization of acid rainwater to improve the quality of the environment.
Astrid Vidya Primadhani +2 more
doaj +1 more source
Rotor redesign for a highly loaded 1800 ft/sec tip speed fan. 1: Aerodynamic and mechanical design report [PDF]
A quasi three dimensional design system and multiple-circular-arc airfoil sections were used to design a fan rotor. An axisymmetric intrablade flow field calculation modeled the shroud of an isolated splitter and radial distribution.
Norton, J. M., Tari, U., Weber, R. M.
core +1 more source