Results 111 to 120 of about 1,297,074 (297)

Circular Product Practices for a Post-Plastic Transition

DIID
The transition toward a post-plastic era challenges designers to develop strategies for the responsible use of polymeric materials within circular models.
Ludovica Rosato
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Stone Circular Design and Material Regeneration

DIID
This contribution aims to investigate the strategic role of design within the ecological transition and the circular economy, through an in-depth analysis of the STONE project.
Gabriele Pontillo, Silvana Bruno, Alessio Tanzini, Fabio Fatiguso   +3 more
doaj   +1 more source

Omni-directional L-band antenna for mobile communications [PDF]

The principle and design of an L-band omni-directional mobile communication antenna are discussed. The antenna is a circular wave guide aperture with hybrid circuits attached to higher order mode excitation.
Kijesky, J., Kim, C. S., Moldovan, N.
core   +1 more source

On designing H∞ filters with circular pole and error variance constraints [PDF]

, 2003
Copyright [2003] IEEE. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's products or services.
Liu, X, Wang, Z
core  

Design of beam optics for the Future Circular Collider e+e- -collider rings

, 2016
A beam optics scheme has been designed for the Future Circular Collider-e+e- (FCC-ee). The main characteristics of the design are: beam energy 45 to 175 GeV, 100 km circumference with two interaction points (IPs) per ring, horizontal crossing angle of 30
Aiba, M., Aumon, S., Benedikt, M., Blondel, A., Bogomyagkov, A., Boscolo, M., Burkhardt, H., Cai, Y., Doblhammer, A., Haerer, B., Holzer, B., Jowett, J. M., Koop, I., Koratzinos, M., Levichev, E., Medina, L., Ohmi, K., Oide, K., Papaphilippou, Y., Piminov, P., Shatilov, D., Sinyatkin, S., Sullivan, M., Wenninger, J., Wienands, U., Zhou, D., Zimmermann, F.   +26 more
core   +2 more sources

Design for Post-Circularity

diid
This paper critically examines the limitations of mainstream circular eco-design approaches and proposes an alternative framework grounded in post-circular thinking. Drawing on futures studies, speculative design, and Emergence theory, it situates eco-design within the evolving context of Industry 5.0.
Paria Bagheri Moghaddam, Giuseppe Lotti
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source