Post‐Translational Isoaspartate Promotes Amyloid Formation in β2‐Microglobulin
Angewandte Chemie, EarlyView.Chemical synthesis of five β2‐microglobulin (β2m) variants reveals the structural impact of Asn deamidation. By introducing Asp or isoAsp at susceptible Asn‐Gly sequences, we demonstrate that isoAsp17 formation specifically accelerates amyloid fibril formation, highlighting its potential contribution to dialysis‐related amyloidosis.
Ryuji Kawakami +5 more
wiley +2 more sources
Chiral Nonlinear Enhancement with Opposite Circular Dichroism Empowered by Dual Bound States in the Continuum. [PDF]
Materials (Basel)Liu X, Wang L, Meng H.
europepmc +1 more source
Redirecting Excited‐State Proton Transfer Through Supramolecular Polymerization in Nanoconfinement
Angewandte Chemie, EarlyView.Supramolecular confinement redirects the excited‐state proton transfer pathway of an amphoteric emitter. In water, the molecule undergoes ESPD, whereas co‐assembly with γ‐cyclodextrin forms nanotubes that template slip‐stacked emitter pairs and enable ESIMPT. Structural and photophysical characterization of the assemblies shows that the preorganization
Luis C. Pantaleone +8 more
wiley +2 more sources
Angularly Tunable Circular Dichroism in a Bilayer Plasmonic Metasurface via Interlayer Coupling. [PDF]
ACS OmegaAsefa SA, Kuiri B, Lee D.
europepmc +1 more source
Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration
Angewandte Chemie, EarlyView.The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti +9 more
wiley +2 more sources
Transfer-Matrix Framework for Modeling Mid-Infrared Vibrational Circular Dichroism Spectra. [PDF]
Anal ChemUtyushev A, Rasskazov IL, Phal Y.
europepmc +1 more source
Mechanically Regulated Nanozymes for Remote Metabolic Reprogramming and Precise Cancer Therapy
Angewandte Chemie, EarlyView.Inspired by mechanoenzymes, a ferrocene‐based mechanically regulated nanozyme converts acoustic shear force into enhanced peroxidase‐like activity by decreasing electron density and alleviating steric hindrance at the Fe active sites, thereby rewiring redox homeostasis. Leveraging this remote regulatory mechanism, a multienzyme‐regulated nanoreactor is
Fangman Chen +13 more
wiley +2 more sources
, 2009 This timely book provides a comprehensive and up-to-date account of circular dichroism (CD) spectroscopy and its application to structural biology. In particular, the newer methods of synchrotron radiation circular dichroism (SRCD) and linear dichroism ...
Wallace, Bonnie A., Janes, R.W.
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Angle-Dependent Terahertz Circular Dichroism and Full-Space Polarization Manipulation via Extrinsic Chiral Metasurfaces. [PDF]
Nanomaterials (Basel)Wan M +11 more
europepmc +1 more source
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources