Results 71 to 80 of about 2,234,197 (338)
Circular RNA: A promising new star of vaccine
Journal of Translational Internal Medicine, 2023 Circular RNAs (circRNAs) are a class of single-stranded RNAs with covalently closed structures. Owing to their not having 3' or 5' ends, circRNAs are highly durable and insusceptible to exonuclease-mediated degradation.
Jindong Xie +10 more
semanticscholar +1 more source
CIRI: an efficient and unbiased algorithm for de novo circular RNA identification
Genome Biology, 2015 Recent studies reveal that circular RNAs (circRNAs) are a novel class of abundant, stable and ubiquitous noncoding RNA molecules in animals. Comprehensive detection of circRNAs from high-throughput transcriptome data is an initial and crucial step to ...
Yuan Gao, Jinfeng Wang, F. Zhao
semanticscholar +1 more source
Synthetic circular RNA switches and circuits that control protein expression in mammalian cells
Nucleic Acids Research, 2023 Synthetic messenger RNA (mRNA) has been focused on as an emerging application for mRNA-based therapies and vaccinations. Recently, synthetic circular RNAs (circRNAs) have shown promise as a new class of synthetic mRNA that enables superior stability and ...
Shigetoshi Kameda +2 more
semanticscholar +1 more source
Nucleic Acids ResearchCircular RNAs (circRNAs) are covalently closed RNAs that are present in all eukaryotes tested. CircRNAs are less abundantly expressed than mRNAs. Recent RNAseq analyses indicate that more than 800,000 circRNA isoforms exist in humans, which is more than twice the number of currently known mRNA isoforms. CircRNAs are generated through backsplicing that
Giorgi Margvelani +4 more
openaire +2 more sources
Circular RNA is expressed across the eukaryotic tree of life. [PDF]
PLoS ONE, 2014 An unexpectedly large fraction of genes in metazoans (human, mouse, zebrafish, worm, fruit fly) express high levels of circularized RNAs containing canonical exons.
Peter L Wang +8 more
doaj +1 more source
Advances in Circular RNA and Its Applications
International Journal of Medical Sciences, 2022 Circular RNA (circRNA) is a novel endogenous non-coding RNA (ncRNA) that, like microRNA (miRNA), is a rapidly emerging RNA research topic. CircRNA, unlike traditional linear RNAs (which have 5' and 3' ends), has a closed-loop structure that is unaffected
Xian-guo Zhao +4 more
semanticscholar +1 more source
An observation of circular RNAs in bacterial RNA-seq data [PDF]
, 2016 Circular RNAs (circRNAs) are a class of RNA with an important role in micro RNA (miRNA) regulation recently discovered in Human and various other eukaryotes as well as in archaea.
Aurell, Erik +3 more
core +1 more source
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular Cancer, 2019 BackgroundCircRNA has emerged as a new non-coding RNA that plays crucial roles in tumour initiation and development. ‘MiRNA sponge’ is the most reported role played by circRNAs in many tumours. The AKT/mTOR axis is a classic signalling pathway in cancers
Xing-Zeng Zhang +10 more
semanticscholar +1 more source