Results 51 to 60 of about 1,315,460 (260)

Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs

Molecules and Cells, 2023
RNAs are versatile molecules that are primarily involved in gene regulation and can thus be widely used to advance the fields of therapeutics and diagnostics. In particular, circular RNAs which are highly stable, have emerged as strong candidates for use on next-generation therapeutic platforms. Endogenous circular RNAs control gene regulatory networks
Mingyu Ju, Dayeon Kim, Geurim Son, Jinju Han   +3 more
openaire   +2 more sources

Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration

Experimental and Molecular Medicine, 2018
Spinal disease: Circular RNA linked to disc degeneration A circular RNA molecule helps protect against degenerative disc disease. Hua Wang and coworkers from Sun Yat-Sen University in Guangzhou, China, examined whether circular RNAs, regulatory molecules
Hua Wang, Peiheng He, Hehai Pan, Jun long, Jianru Wang, Zemin Li, Hui Liu, Weiying Jiang, Zhaomin Zheng   +8 more
doaj   +1 more source

Circular RNAs in myogenesis

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020
Skeletal muscles have an immense ability to regenerate from the muscle stem cells called satellite cells. The process of skeletal muscle regeneration is called myogenesis, which starts with activation of quiescent satellite cells immediately after muscle injury followed by proliferation and fusion of myoblasts into myotubes.
Arundhati, Das, Aniruddha, Das, Debojyoti, Das, Kotb, Abdelmohsen, Amaresh C, Panda   +4 more
openaire   +3 more sources

CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin

Frontiers in Bioinformatics, 2022
Distinguishing circular RNA reads from reads derived from the linear host transcript is a challenging task because of sequence overlap. We developed a computational approach, CiLiQuant, that determines the relative circular and linear abundance of ...
Annelien Morlion, Annelien Morlion, Eva Hulstaert, Eva Hulstaert, Marieke Vromman, Marieke Vromman, Jasper Anckaert, Jasper Anckaert, Celine Everaert, Celine Everaert, Jo Vandesompele, Jo Vandesompele, Pieter Mestdagh, Pieter Mestdagh   +13 more
doaj   +1 more source

Interior circular RNA [PDF]

RNA Biology, 2019
Formed by back splicing or back fusion of linear RNAs, circular RNAs (circRNAs) constitute a new class of non-coding RNAs of eukaryotes. Recent studies reveal a spliceosome-dependent biogenesis of circRNAs where circRNAs arise at the intron-exon junctions of mRNAs.
Xiaoxin Liu, Zhangfeng Hu, Junfei Zhou, Cheng Tian, Guangmei Tian, Miao He, Lifen Gao, Lihong Chen, Tiantian Li, Hai Peng, Weixiong Zhang   +10 more
openaire   +2 more sources

An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]

, 2013
Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354), Jack O Phillips, Anastasia J Callaghan, Vincent, H., Andrew R. Pickford (485355), Adam J Roberts, Louise E. Butt (485353), Stone, Carlanne, Charlotte E. Mardle (485352), Henderson, Charlotte, Adam J. Roberts (485350), Pickford, Andy, Carlanne M Stone, Roberts, Adam J., Butt, Louise, Charlotte A Henderson, Louise E Butt, Anastasia J. Callaghan (485356), Helen A Vincent, Charlotte E Mardle, Callaghan, Anastasia, Carlanne M. Stone (485351), Phillips, Jack, Jack O. Phillips (485348), Charlotte A. Henderson (485349), Gowers, Darren, Mardle, C., Andrew R Pickford, Helen A. Vincent (485347), Darren M Gowers   +29 more
core   +2 more sources

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]

, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Richard M. Elliott, Böttcher, Bettina, Li, P., Dong, H., Li, Ping, Dong, Changjiang, Dong, Haohao, Elliott, R., Boettcher, Bettina, Elliott, Richard M., Bottcher, B., Haohao Dong, Bettina Böttcher, Ping Li, Elliott, Richard M, Dong, C., Changjiang Dong   +16 more
core   +1 more source

Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs

Frontiers in Microbiology, 2021
Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5′ and 3′ ends have been joined, which confers protection from RNA exonucleases. We examined the expression
Takanobu Tagawa, Daniel Oh, Jerico Santos, Jerico Santos, Sarah Dremel, Guruswamy Mahesh, Thomas S. Uldrick, Robert Yarchoan, Vishal N. Kopardé, Vishal N. Kopardé, Joseph M. Ziegelbauer   +10 more
doaj   +1 more source

Axon micro-dissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons [PDF]

, 2020
Axonal protein synthesis has been shown to play a role in developmental and regenerative growth, as well as in the maintenance of the axoplasm in steady state.
Sotelo-Silveira, José Roberto, Farías, Joaquina, Sotelo Sosa, José Roberto, Holt, C. E.   +3 more
core   +3 more sources

Cost-Effective Transcriptome-Wide Profiling of Circular RNAs by the Improved-tdMDA-NGS Method

Frontiers in Molecular Biosciences, 2022
Covalently closed circular RNAs are neoteric to the eukaryotic family of long non-coding RNAs emerging as a result of 5′–3′ backsplicing from exonic, intronic, or intergenic regions spanning the parental gene.
Ashirbad Guria, Priyanka Sharma, Nagesh Srikakulam, Akhil Baby, Sankar Natesan, Gopal Pandi   +5 more
doaj   +1 more source