Results 31 to 40 of about 160,128 (263)
Circular RNA identified from Peg3 and Igf2r. [PDF]
PLoS ONE, 2018 Circular RNA is a newly discovered class of non-coding RNA generated through the back-splicing of linear pre-mRNA. In the current study, we characterized two circular RNAs that had been identified through NGS-based 5'RACE experiments.
Bambarendage P U Perera +2 more
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RNA Biology, 2019 Formed by back splicing or back fusion of linear RNAs, circular RNAs (circRNAs) constitute a new class of non-coding RNAs of eukaryotes. Recent studies reveal a spliceosome-dependent biogenesis of circRNAs where circRNAs arise at the intron-exon junctions of mRNAs.
Xiaoxin Liu +10 more
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Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs
Molecules and Cells, 2023 RNAs are versatile molecules that are primarily involved in gene regulation and can thus be widely used to advance the fields of therapeutics and diagnostics. In particular, circular RNAs which are highly stable, have emerged as strong candidates for use on next-generation therapeutic platforms. Endogenous circular RNAs control gene regulatory networks
Mingyu Ju +3 more
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Experimental and Molecular Medicine, 2018 Spinal disease: Circular RNA linked to disc degeneration A circular RNA molecule helps protect against degenerative disc disease. Hua Wang and coworkers from Sun Yat-Sen University in Guangzhou, China, examined whether circular RNAs, regulatory molecules
Hua Wang +8 more
doaj +1 more source
CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin
Frontiers in Bioinformatics, 2022 Distinguishing circular RNA reads from reads derived from the linear host transcript is a challenging task because of sequence overlap. We developed a computational approach, CiLiQuant, that determines the relative circular and linear abundance of ...
Annelien Morlion +13 more
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Circular RNA Regulation of Myogenesis
Cells, 2019 Circular RNA (circRNA) is a novel class of non-coding RNA generated by pre-mRNA back splicing, which is characterized by a closed-loop structure. Although circRNAs were firstly reported decades ago, their regulatory roles have not been discovered until ...
Pengpeng Zhang +10 more
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Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs
Frontiers in Microbiology, 2021 Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5′ and 3′ ends have been joined, which confers protection from RNA exonucleases. We examined the expression
Takanobu Tagawa +10 more
doaj +1 more source
Cell Transplantation, 2019 Emerging evidence demonstrates that dysregulation of circular RNA is linked to tumorigenesis and aggressive progression. However, its role in oral squamous cell carcinoma remains largely uncharacterized.
Bing Xia +4 more
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Cost-Effective Transcriptome-Wide Profiling of Circular RNAs by the Improved-tdMDA-NGS Method
Frontiers in Molecular Biosciences, 2022 Covalently closed circular RNAs are neoteric to the eukaryotic family of long non-coding RNAs emerging as a result of 5′–3′ backsplicing from exonic, intronic, or intergenic regions spanning the parental gene.
Ashirbad Guria +5 more
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Nucleic Acids ResearchCircular RNAs (circRNAs) are covalently closed RNAs that are present in all eukaryotes tested. CircRNAs are less abundantly expressed than mRNAs. Recent RNAseq analyses indicate that more than 800,000 circRNA isoforms exist in humans, which is more than twice the number of currently known mRNA isoforms. CircRNAs are generated through backsplicing that
Giorgi Margvelani +4 more
openaire +2 more sources