Results 31 to 40 of about 1,315,460 (260)
Frontiers in Immunology, 2022 Circular DNAs derived from single-stranded RNA viruses play important roles in counteracting viral infection. However, whether double-stranded RNA viruses generate functional circular DNAs is still unknown. Using circDNA sequencing, divergent PCR, DNA in
Min Zhu +13 more
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CircMarker: a fast and accurate algorithm for circular RNA detection
BMC Genomics, 2018 Background While RNA is often created from linear splicing during transcription, recent studies have found that non-canonical splicing sometimes occurs. Non-canonical splicing joins 3’ and 5’ and forms the so-called circular RNA.
Xin Li +4 more
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What goes around comes around: Artificial circular RNAs bypass cellular antiviral responses
Molecular Therapy: Nucleic Acids, 2022 Natural circular RNAs have been found to sequester microRNAs and suppress their function. We have used this principle as a molecular tool and produced artificial circular RNA sponges in a cell-free system by in vitro transcription and ligation. Formerly,
Janina Breuer +6 more
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In vitro circularization of RNA [PDF]
RNA Biology, 2016 Over the past 2 decades, different types of circular RNAs have been discovered in all kingdoms of life, and apparently, those circular species are more abundant than previously thought. Apart from circRNAs in viroids and viruses, circular transcripts have been discovered in rodents more than 20 y ago and recently have been reported to be abundant in ...
Sabine, Müller, Bettina, Appel
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Circular RNA in Diseased Heart
Cells, 2020 Heart disease remains the leading cause of death globally and leads to tremendous socio-economic burden. Despite advances in the field of cardiovascular research, novel theranostics are still in urgent need.
Ying Wang, Bin Liu
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Mechanisms of circular RNA degradation
Communications Biology, 2022 In this Perspective, Longxin Ren and co-authors summarise the role of circular RNAs in disease and discuss recent insights into how circular RNAs are metabolised in the cell.
Longxin Ren +7 more
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CIRCexplorer3: A CLEAR Pipeline for Direct Comparison of Circular and Linear RNA Expression
Genomics, Proteomics & Bioinformatics, 2019 Sequences of circular RNAs (circRNAs) produced from back-splicing of exon(s) completely overlap with those from cognate linear RNAs transcribed from the same gene loci with the exception of their back-splicing junction (BSJ) sites. Therefore, examination
Xu-Kai Ma +6 more
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Circular RNA in gastric cancer
Chinese Medical Journal, 2020 . Gastric cancer (GC) is a common malignancy and is the third leading cause of cancer-related death. At present, there is no simple and effective screening method for early-stage GC, and the treatment results and prognosis are poor.
Xue-Wei Li +3 more
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Cancer Cell International, 2021 Background Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors.
Jing Han +5 more
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Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway [PDF]
, 2012 tRNA precursors, which are transcribed by RNA polymerase III, undergo end-maturation, splicing and base modifications. Hypomodified tRNAs, such as tRNAVal(AAC), lacking 7-methylguanosine and 5-methylcytidine modifications, are subject to degradation by a
Boguta, Magdalena +3 more
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