Results 21 to 30 of about 169,673 (308)
Research progress of circular RNA zinc finger RNA binding protein in malignant tumors [PDF]
Jichu yixue yu linchuang, 2022 Circular RNA is a kind of RNA molecule with special covalent closed circular structure. The existing research results showed that circular RNA zinc finger RNA binding protein (circRNA-ZFR) was abnormally expressed in many malignant tumors, and its ...
LIU Lang, WANG Hai-cun, GAO Xin, LIU Guang-lin, ZHAO Yu-qiao, JIANG Xing-ming
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A Split NanoLuc Reporter Quantitatively Measures Circular RNA IRES Translation
, 2022 Internal ribosomal entry sites (IRESs) are RNA secondary structures that mediate translation independent from the m7G RNA cap. The dicistronic luciferase assay is the most frequently used method to measure IRES-mediated translation.
Haley A. MacNeil +11 more
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Biogenesis of Circular RNAs [PDF]
Cell, 2014 Circular RNAs are generated during splicing through various mechanisms. Ashwal-Fluss et al. demonstrate that exon circularization and linear splicing compete with each other in a tissue-specific fashion, and Zhang et al. show that exon circularization depends on flanking intronic complementary sequences.
Vicens, Quentin, Westhof, Eric
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Frontiers in Immunology, 2022 Circular DNAs derived from single-stranded RNA viruses play important roles in counteracting viral infection. However, whether double-stranded RNA viruses generate functional circular DNAs is still unknown. Using circDNA sequencing, divergent PCR, DNA in
Min Zhu +13 more
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Functions of Circular RNA in Human Diseases and Illnesses
, 2023 Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free ends.
Dabbu Kumar Jaijyan +5 more
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Circular RNA in gastric cancer
Chinese Medical Journal, 2020 . Gastric cancer (GC) is a common malignancy and is the third leading cause of cancer-related death. At present, there is no simple and effective screening method for early-stage GC, and the treatment results and prognosis are poor.
Xue-Wei Li +3 more
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What goes around comes around: Artificial circular RNAs bypass cellular antiviral responses
Molecular Therapy: Nucleic Acids, 2022 Natural circular RNAs have been found to sequester microRNAs and suppress their function. We have used this principle as a molecular tool and produced artificial circular RNA sponges in a cell-free system by in vitro transcription and ligation. Formerly,
Janina Breuer +6 more
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CIRCexplorer3: A CLEAR Pipeline for Direct Comparison of Circular and Linear RNA Expression
Genomics, Proteomics & Bioinformatics, 2019 Sequences of circular RNAs (circRNAs) produced from back-splicing of exon(s) completely overlap with those from cognate linear RNAs transcribed from the same gene loci with the exception of their back-splicing junction (BSJ) sites. Therefore, examination
Xu-Kai Ma +6 more
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Mechanisms of circular RNA degradation
Communications Biology, 2022 In this Perspective, Longxin Ren and co-authors summarise the role of circular RNAs in disease and discuss recent insights into how circular RNAs are metabolised in the cell.
Longxin Ren +7 more
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Emerging Role of Circular RNA–Protein Interactions
, 2021 Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate ...
Tanvi Sinha +3 more
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