Results 1 to 10 of about 1,315,460 (260)

Circular RNA is expressed across the eukaryotic tree of life. [PDF]

PLoS ONE, 2014
An unexpectedly large fraction of genes in metazoans (human, mouse, zebrafish, worm, fruit fly) express high levels of circularized RNAs containing canonical exons.
Peter L Wang, Yun Bao, Muh-Ching Yee, Steven P Barrett, Gregory J Hogan, Mari N Olsen, José R Dinneny, Patrick O Brown, Julia Salzman   +8 more
doaj   +1 more source

CircSeqAlignTk: An R package for end-to-end analysis of RNA-seq data for circular genomes [version 1; peer review: 1 approved, 2 approved with reservations]

F1000Research, 2022
RNA sequencing (RNA-seq) technology has now become one of the standard tools for studying biological mechanisms at the transcriptome level. Advances in RNA-seq technology have led to the emergence of a large number of publicly available tools for RNA-seq
Wei Cao, Jianqiang Sun, Xi Fu
doaj   +1 more source

Circular RNA Expression Profile in Cervical Cancer and Construction of the Circular RNA‑MicroRNA‑Messenger RNA Regulatory Network

Креативная хирургия и онкология
Introduction. Cervical cancer (CC) remains the most common cancer in women worldwide. However, effective and specific biomarkers for the diagnosis and prognosis of cervical cancer are yet to be found.
S. A. Begliarzade, R. I. Tamrazov, E. R. Musaev, C. Wang   +3 more
doaj   +1 more source

Construction of transcriptional regulatory networks using total RNA-seq data

STAR Protocols, 2021
Summary: Total RNA sequencing allows capturing of long non-coding and circular RNA along with mRNA. Additional sequencing of micro RNA (miRNA), using libraries with shorter fragments, provides the means to characterize miRNA-driven transcriptional ...
Philippe Chouvarine, Georg Hansmann
doaj   +1 more source

Hybrids of RNA viruses and viroid-like elements replicate in fungi

Nature Communications, 2023
Earth’s life may have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymerase
Marco Forgia, Beatriz Navarro, Stefania Daghino, Amelia Cervera, Andreas Gisel, Silvia Perotto, Dilzara N. Aghayeva, Mary F. Akinyuwa, Emanuela Gobbi, Ivan N. Zheludev, Robert C. Edgar, Rayan Chikhi, Massimo Turina, Artem Babaian, Francesco Di Serio, Marcos de la Peña   +15 more
doaj   +1 more source

Research progress on circular RNA vaccines

Frontiers in Immunology, 2023
Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results ...
Yu Bai, Yu Bai, Yu Bai, Dong Liu, Dong Liu, Dong Liu, Qian He, Qian He, Qian He, Jianyang Liu, Jianyang Liu, Jianyang Liu, Qunying Mao, Qunying Mao, Qunying Mao, Zhenglun Liang, Zhenglun Liang, Zhenglun Liang   +17 more
doaj   +1 more source

circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

Nature Communications, 2019
Circular RNAs are known to regulate cancer. Here, the authors show that the circular RNA circTP63 promotes lung squamous cell carcinoma by competing with endogenous RNA to upregulate FOXM1.
Zhuoan Cheng, Chengtao Yu, Shaohua Cui, Hui Wang, Haojie Jin, Cun Wang, Botai Li, Meilin Qin, Chen Yang, Jia He, Qiaozhu Zuo, Siying Wang, Jun Liu, Weidong Ye, Yuanyuan Lv, Fangyu Zhao, Ming Yao, Liyan Jiang, Wenxin Qin   +18 more
doaj   +1 more source

The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia

Cells, 2020
Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation.
Artem Nedoluzhko, Natalia Gruzdeva, Fedor Sharko, Sergey Rastorguev, Natalia Zakharova, Georgy Kostyuk, Vadim Ushakov   +6 more
doaj   +1 more source

Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p

Technology in Cancer Research & Treatment, 2020
This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer.
Ziqi Peng BM, Boyang Xu BM, Feng Jin MD
doaj   +1 more source

Cancer-related circular RNA: diverse biological functions

Cancer Cell International, 2021
Noncoding RNAs, including long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs), are involved in regulating biological functions.
Dan Cheng, Jing Wang, Zigang Dong, Xiang Li   +3 more
doaj   +1 more source