Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis [PDF]
Molecular Cell, 2017 Summary Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the ...
Ivano Legnini +2 more
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Cell-type specific features of circular RNA expression. [PDF]
PLoS Genetics, 2013 Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle. Using an improved computational approach for circular RNA identification, we found widespread circular
Julia Salzman +4 more
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Circular RNA vaccines against SARS-CoV-2 and emerging variants
Cell, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its emerging variants of concern (VOC), such as Delta (B.1.617.2) and Omicron (B.1.1.529), has continued to drive the worldwide pandemic. Therefore, there is a high demand for vaccines with
Liang Qu, Zongyi Yi, Feng Chen
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The Landscape of Circular RNA in Cancer
Cell, 2019 Circular RNAs (circRNAs) are an intriguing class of RNA due to their covalently closed structure, high stability, and implicated roles in gene regulation.
Marcin Cieslik +2 more
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Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines
Journal of Controlled Release, 2022 Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5' or 3' ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA degradation by exonucleases, thereby empowering them with high ...
Guizhi Zhu
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Circular RNA in hepatocellular carcinoma: emerging therapeutic strategies [PDF]
Frontiers in ImmunologyCircular RNAs, or circRNAs, are unique single-stranded RNA molecules that form covalently closed circles. They possess a wide range of cellular functions and can act as tumor suppressors or promoters, regulating various aspects of carcinogenesis.
Gregor Jazbec, Tadeja Režen
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Expression Significance of Serum Circular RNA CDYL and Circular RNA ROBO2 in Patients with Acute Myocardial Infarction and the Value of Their Combined Prediction for Major Adverse Cardiovascular Events [PDF]
International Journal of General MedicineFang Wang, Rui Liu, Cuirong Zhang, Shenglin Liu Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, People’s Republic of ChinaCorrespondence: Shenglin Liu, Email isl0076@163.comObjective: To ...
Wang F, Liu R, Zhang C, Liu S
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Research progress on circular RNA vaccines
Frontiers in Immunology, 2023 Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results ...
Yu Bai +17 more
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N6-Methyladenosine Modification Controls Circular RNA Immunity
Molecular Cell, 2019 Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self versus foreign identity in circRNA immunity is unknown.
Y Grace Chen +2 more
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Circular RNA Expression: Its Potential Regulation and Function
Trends in Genetics, 2016 Julia Salzman
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