Results 191 to 200 of about 52,233 (242)

Geographical and temporal trends of HIV-1 subtypes and drug resistance in China: a nationwide study over two decades (2003-2024). [PDF]

J Gen Virol
Xie B, Wang Z, Song Q, Cui M, Deng Y, Zheng F, Krol E, Khouri R, De Clercq E, Mo J, Li G.   +10 more
europepmc   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Identification of a novel HIV-1 circulating recombinant form CRF157_A6C in Primorsky Territory, Russia

Journal of Infection
Maksim R, Halikov, Vasily E, Ekushov, Alexei V, Totmenin, Natalya M, Gashnikova, Mariya E, Antonets, Tatyana V, Tregubchak, Lidiia P, Skliar, Natalia P, Solovyova, Irina S, Gorelova, Svetlana N, Beniova   +9 more
openaire   +2 more sources

Opportunities and challenges in recurrent diffuse podocytopathy post-transplantation: the critical value of the definition. [PDF]

Front Immunol
Nuccitelli R, Toutoungis A, Martinelli E, Sanna-Cherchi S, Weins A, Morris HK, Bomback AS, Batal I.   +7 more
europepmc   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Functional, biochemical, and clinical characterization of natural mutations affecting arginine residues in the heparin-binding site of antithrombin. [PDF]

Hemasphere
Cifuentes-Riquelme R, de la Morena-Barrio ME, Miñano A, Garrido-Rodríguez P, Velasco F, Rojo-Carrillo JJ, López-Correas P, Zaragoza-Huesca D, Padilla J, Lozano ML, Bravo-Pérez C, Corral J.   +11 more
europepmc   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Evolutionary dynamics of HIV-1 recombinants: analysis of contemporary and historical viral populations in East Africa. [PDF]

Virol J
Balinda SN, Kapaata A, Kato F, Nakyanzi A, Natwijuka F, Ndekezi C, Byamukama D, Omara D, Mugaba S, Obuku AE, Salazar-Gonzalez JF, Kaleebu P.   +11 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Targeted anticoagulant reversal, unintended consequences: lessons from andexanet alfa. [PDF]

Eur Heart J Cardiovasc Pharmacother
Levy JH, Shaw JR.
europepmc   +1 more source